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Brain State Dependent Activity in the Cortex and Thalamus

机译:大脑皮层和丘脑中的大脑状态依赖性活动

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摘要

Cortical and thalamocortical activity is highly state dependent, varying between patterns of activity that are conducive to accurate sensory-motor processing, to states in which the brain is largely off-line and generating internal rhythms irrespective of the outside world. The generation of rhythmic activity occurs through the interaction of stereotyped patterns of connectivity together with intrinsic membrane and synaptic properties. One common theme in the generation of rhythms is the interaction of a positive feedback loop (e.g. recurrent excitation) with negative feedback control (e.g. inhibition, adaptation, or synaptic depression). The operation of these state-dependent activities has wide ranging effects from enhancing or blocking sensory-motor processing to the generation of pathological rhythms associated with psychiatric or neurological disorders.
机译:皮质和丘脑皮质活动高度依赖于状态,在有助于准确进行感觉运动处理的活动模式之间变化,在这种状态下大脑大部分处于脱机状态并产生内部节奏,而与外界无关。节律活动的产生是通过连接的定型模式与固有膜和突触特性的相互作用而发生的。节律产生中的一个常见主题是正反馈回路(例如,反复激发)与负反馈控制(例如,抑制,适应或突触抑制)的相互作用。这些状态相关活动的操作具有广泛的影响,从增强或阻止感觉运动处理到与精神病或神经病相关的病理性节律的产生。

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