• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Systemic administration of the neurotensin NTS1 receptor agonist PD149163 improves performance on a memory task in naturally deficient male Brown Norway rats
【2h】

Systemic administration of the neurotensin NTS1 receptor agonist PD149163 improves performance on a memory task in naturally deficient male Brown Norway rats

机译：系统性给予神经降压素NTS1受体激动剂PD149163可改善自然缺乏的雄性布朗挪威大鼠记忆任务的表现

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Agonists for neurotensin NTS1 receptor consistently exhibit antipsychotic effects in animal models without producing catalepsy, suggesting that NTS1 receptor agonists may be a novel class of drugs to treat schizophrenia. Moreover, studies utilizing NTS1 agonists have reported improvements in some aspects of cognitive functioning, including prepulse inhibition and learning procedures, that suggest an ability of NTS1 receptor agonists to diminish neurocognitive deficits. The present study sought to assess both baseline delay-induced memory performance and the effects of NTS1 receptor activation on learning and memory consolidation in male Long Evans and Brown Norway rats using a delayed non-match to position radial arm maze task. In the absence of drugs, Brown Norway rats displayed a significant increase in spatial memory errors following a 3, 7, and 24 hour delay, whereas Long Evans rats exhibited an increase in spatial memory errors following only a 7 and 24 hour delay. With Brown Norway rats, administration of PD149163 before or after an information trial significantly reduced errors during a retention trial after a 24 hour delay. Administration of the NTS1/2 receptor antagonist SR142948 prior to the information trial did not affect retention trial errors. These data are consistent with previous findings that Brown Norway rats have natural cognitive deficits and that they may be useful for assessing putative antipsychotic drugs for cognitive efficacy. Moreover, this study supports previous findings suggesting that NTS1 receptor agonists may improve some aspects of cognitive functioning.
机译：神经降压素NTS1受体激动剂在动物模型中始终表现出抗精神病作用，而不会产生僵直性僵直，这表明NTS1受体激动剂可能是治疗精神分裂症的新型药物。此外，利用NTS1激动剂的研究已经报道了认知功能在某些方面的改善，包括脉冲前抑制和学习程序，这表明NTS1受体激动剂具有减轻神经认知缺陷的能力。本研究试图通过延迟不匹配来定位radial臂迷宫任务来评估基线延迟诱导的记忆表现以及NTS1受体激活对雄性Long Evans和Brown Norweg大鼠学习和记忆巩固的影响。在没有药物的情况下，褐挪威大鼠在延迟3、7和24小时后显示出明显的空间记忆错误，而朗伊文斯大鼠仅在延迟7和24小时后显示出了空间记忆错误增加。对于褐挪威鼠，在信息试验之前或之后施用PD149163可以显着减少24小时延迟后的保留试验期间的错误。在信息试验之前给予NTS1 / 2受体拮抗剂SR142948不会影响保留试验的错误。这些数据与先前的发现一致，即布朗挪威大鼠具有自然的认知缺陷，并且它们可能用于评估公认的抗精神病药的认知功效。此外，这项研究支持以前的发现，暗示NTS1受体激动剂可能会改善认知功能的某些方面。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号