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A Randomized Controlled Trial of an Internet-Based Therapist-Assisted Indicated Preventive Intervention for Prolonged Grief Disorder

机译:基于互联网的治疗师辅助的针对长期悲伤疾病的指示性预防干预的随机对照试验

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摘要

This trial assessed the feasibility, acceptability, tolerability, and efficacy of an Internet-based therapist-assisted cognitive-behavioral indicated prevention intervention for prolonged grief disorder (PGD) called Healthy Experiences After Loss (HEAL). Eighty-four bereaved individuals at risk for PGD were randomized to either an immediate treatment group (n = 41) or a waitlist control group (n=43). Assessments were conducted at four time-points: prior to the wait-interval (for the waitlist group), pre-intervention, post-intervention, 6 weeks later, and 3 months later (for the immediate group only). Intent-to-treat analyses indicated that HEAL was associated with large reductions in prolonged grief (d=1.10), depression (d=.71), anxiety (d=.51), and posttraumatic stress (d=.91). Also, significantly fewer participants in the immediate group met PGD criteria post-intervention than in the waitlist group. Pooled data from both groups also yielded significant reductions and large effect sizes in PGD symptom severity at each follow-up assessment. The intervention required minimal professional oversight and ratings of satisfaction with treatment and usability of the Internet interface were high. HEAL has the potential to be an effective, well-tolerated tool to reduce the burden of significant pre-clinical PGD. Further research is needed to refine HEAL and to assess its efficacy and mechanisms of action in a large-scale trial.
机译:该试验评估了基于互联网的治疗师辅助的认知行为指征的预防,干预措施,适用于长期悲伤症(PGD),称为“失落后健康经历”(HEAL),其可行性,可接受性,耐受性和功效。八十四例有PGD危险的丧亲者被随机分为即刻治疗组(n = 41)或候补对照组(n = 43)。在四个时间点进行评估:在等待间隔之前(对于等待列表组),干预前,干预后,6周后和3个月后(仅对于直接组)。意图治疗分析表明,HEAL与长期悲伤(d = 1.10),抑郁(d = .71),焦虑(d = .51)和创伤后应激(d = .91)的大量减少有关。此外,与等待列表组相比,直接干预组中符合PGD标准的参与者在干预后的数量要少得多。两组的汇总数据在每次随访评估中也均显着降低了PGD症状的严重程度,并产生了较大的影响。干预需要最少的专业监督,并且对互联网接口的治疗和可用性的满意程度很高。 HEAL有潜力成为一种有效且耐受性良好的工具,以减轻临床前大量PGD的负担。在大规模试验中,需要进一步研究以完善HEAL并评估其疗效和作用机制。

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