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首页> 美国卫生研究院文献>other >Comparative Transcriptome Analysis Reveals Significant Differences in MicroRNA Expression and Their Target Genes between Adipose and Muscular Tissues in Cattle
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Comparative Transcriptome Analysis Reveals Significant Differences in MicroRNA Expression and Their Target Genes between Adipose and Muscular Tissues in Cattle

机译：比较转录组分析揭示了牛脂肪组织和肌肉组织中MicroRNA表达及其靶基因的显着差异

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摘要

The posttranscriptional gene regulation mediated by microRNAs (miRNAs) plays an important role in various species. However, to date limited miRNAs have been reported between fat and muscle tissues in beef cattle. In this paper, 412 known and 22 novel miRNAs in backfat as well as 334 known and 10 novel miRNAs in longissimus thoracis were identified in the Chinese Qinchuan beef cattle. Bta-miR-199a-3p, -154c, -320a and -432 were expressed at higher levels in backfat tissue, while bta-miR-1, -133a, -206, and -378 were also significantly enriched in muscle tissue. Functional analysis revealed that fat-enriched miRNAs targeted PRKAA1/2, PPARA and PPARG genes to modulate lipid and fatty acid metabolism, and muscle-enriched miRNAs targeted CSRP3 gene to present function involved in skeletal and muscular system development. The results obtained may help in the design of new selection strategies to improve beef quality.
机译：microRNA（miRNA）介导的转录后基因调控在各种物种中起重要作用。然而，迄今为止，已报道了肉牛脂肪和肌肉组织之间有限的miRNA。在本文中，在中国秦川肉牛中鉴定出背脂肪中的412种已知miRNA和22种新颖miRNA，以及在长统胸中的334种已知miRNA和10种新颖miRNA。 Bta-miR-199a-3p，-154c，-320a和-432在后脂肪组织中表达较高，而bta-miR-1，-133a，-206和-378在肌肉组织中也显着富集。功能分析表明，富含脂肪的miRNA靶向PRKAA1 / 2，PPARA和PPARG基因，以调节脂质和脂肪酸代谢，而富含肌肉的miRNA靶向CSRP3基因，以发挥参与骨骼和肌肉系统发育的功能。获得的结果可能有助于设计新的选择策略以改善牛肉质量。

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