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首页> 美国卫生研究院文献>The Journal of Experimental Medicine >Structure expression and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3
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Structure expression and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3

机译：小鼠BCM1（OX45或Blast-1）抗原的结构表达和遗传连锁。遗传复制的证据产生了小鼠染色体1上的BCM1区和小鼠染色体3上的CD2 / LFA3区

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The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily. Mouse BCM1 is widely expressed on leukocytes and is likely to be anchored to the cell surface by a glycosyl-phosphatidylinositol anchor, as is the case for rat and human BCM1 antigen. Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3). A similar relationship was established between the human BCM1 locus (BCM1) and ATP1A2, and other markers on chromosome 1q. Conservation of genomic organization within a segment of human chromosome 1q and mouse chromosome 1 was demonstrated. A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p. Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa- 3/ATP1A2 on chromosomes 1 (mouse) and 1q (human). Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed. The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 and LFA3, and if the precursors of the CD2 and LFA3 loci formed before the proposed chromosome segment duplication, then a gene encoding a recognizer molecule for BCM1 may exist in linkage with Bcm-1/BCM1 on chromosome 1 (mouse) and 1q (human).
机译：小鼠BCM1（OX45，Blast-1）抗原已被cDNA克隆和测序，以提供支持BCM1，LFA3和CD2构成Ig超家族亚组的数据。小鼠BCM1在白细胞上广泛表达，并且可能像大鼠和人BCM1抗原一样，被糖基磷脂酰肌醇锚定到细胞表面。通过重组和脉冲场分析进行的遗传连锁研究显示，BCM1基因座（Bcm-1）位于小鼠远端1号染色体上，并在1600 kb之内与ATPaseα链基因（Atpa-3）的基因座相连。在人类BCM1基因座（BCM1）和ATP1A2与1q号染色体上的其他标记之间建立了相似的关系。证明了人类染色体1q和小鼠染色体1片段内的基因组组织的保守性。在小鼠染色体3和人类染色体1p之间的CD2和LFA3基因区域中也看到了类似的情况。此外，CD2 / LFA3基因在580 kb内与Atpa-1 / ATP1A1基因连接，从而为Bcm-1 / BCM1与Atpa-3 / ATP1A2在1号染色体（小鼠）和1q基因（人类）之间的连接提供了类似的情况。 。综上所述，数据表明，包括BCM1，CD2和LFA3的基因前体以及ATPase基因的染色体区域重复，从而形成了现在观察到的连接基团。复制的区域可能在人类的1号染色体上保持在一起（着丝粒的插入），而在小鼠中，遗传区域被建议分散在1号和3号染色体的形成中。CD2和LFA3更多与BCM1和LFA3的序列不同，并且如果CD2和LFA3基因座的前体在拟议的染色体片段复制之前形成，则编码BCM1识别分子的基因可能与1号染色体上的Bcm-1 / BCM1连接（小鼠） ）和1q（人类）。

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