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首页> 美国卫生研究院文献>other >Inactivation of the Nucleus Accumbens Core or Medial Shell Attenuates Reinstatement of Sugar-Seeking Behavior following Sugar Priming or Exposure to Food-Associated Cues
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Inactivation of the Nucleus Accumbens Core or Medial Shell Attenuates Reinstatement of Sugar-Seeking Behavior following Sugar Priming or Exposure to Food-Associated Cues

机译：伏隔核核心或中间壳的失活削弱了糖引发或暴露于食物相关线索后糖的寻觅行为的恢复。

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摘要

Re-exposure to either palatable food or to conditioned stimuli associated with food is known to reinstate food-seeking after periods of abstinence. The nucleus accumbens core and shell are important for reinstatement in both food- and drug-seeking paradigms, although their potential differential roles have been difficult to delineate due to methodological differences in paradigms across laboratories. The present studies assessed the effects of temporary inactivation of the core or shell on priming- and cue-induced reinstatement of food-seeking in identically-trained rats. Inactivation of either the nucleus accumbens core (Experiment 1A; N = 10) or medial shell (Experiment 1B; N = 12) blocked priming-induced reinstatement in an equivalent manner. Similarly, inactivation of the core or medial shell (Experiments 2A & 2B; N = 11 each) also blocked cue-induced reinstatement, although there was also a significant treatment day X brain region X drug order interaction. Specifically, rats with core inactivation reinstated lever-pressing on the vehicle injection day regardless of whether that was their first or second test, whereas rats that had medial shell inactivation on the first day did not significantly reinstate lever-pressing on the second day of testing (when they received vehicle). Yohimbine, while a reportedly robust pharmacological stressor, was ineffective at inducing reinstatement in the current stress-induced reinstatement procedure. These data suggest that both the nucleus accumbens core and shell serve important roles in reinstatement of food-seeking in response to priming and cues.
机译：禁食一段时间后，再暴露于可口的食物或与食物相关的条件刺激下，可以重新寻找食物。伏隔核的核和壳对于在寻求食物和寻求毒品的范例中的恢复都很重要，尽管由于实验室之间范式在方法上的差异而难以界定它们的潜在差异作用。本研究评估了在相同训练的大鼠中，核或壳的暂时失活对引发和暗示诱导的觅食恢复的影响。伏伏核核心（实验1A； N = 10）或内侧壳（实验1B； N = 12）的失活以同样的方式阻止了启动诱导的修复。相似地，尽管也存在显着的治疗日X脑区域X药物顺序相互作用，但核壳或内侧壳的失活（实验2A和2B；每个N = 11）也阻止了提示诱导的恢复。具体而言，具有核心失活作用的大鼠在媒介物注射当天恢复了杠杆压制，而不论是第一次还是第二次测试，而在第一天具有中间壳失活的大鼠在测试的第二天并未显着恢复杠杆压制（当他们收到车辆时）。育亨宾虽然据称是强大的药理应激源，但在目前的应激诱导的恢复程序中不能有效地诱导恢复。这些数据表明伏隔核的核和壳在响应于启动和提示而恢复觅食中起着重要作用。

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    Peagan Lin; Wayne E. Pratt;

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  • 年(卷),期 -1(9),6
  • 年度 -1
  • 页码 e99301
  • 总页数 10
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