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首页> 美国卫生研究院文献>The Journal of Experimental Medicine >Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution
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Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution

机译：人类Ig Lambda 1基因的基因组结构表明它可能以Ig Lambda 14.1样蛋白或经典B细胞Ig Lambda轻链表达：对Ig Lambda基因进化的影响

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摘要

In pre-B cells, immunoglobulin mu (Ig mu) is associated with pre-B cell- specific proteins to form a multimeric complex that is found on the cell surface. One of these proteins is encoded by the three exon Ig lambda-like gene 14.1, whose expression is restricted to pre-B cells and occurs from an unrearranged gene. A comparison of the 14.1 gene structure to the seven-gene human Ig lambda locus revealed that the most 5' gene, Ig lambda 1, is organized in a three-exon structure very similar to the 14.1 gene. Transcription and splicing of these three- exon sequences would lead to an mRNA with an open reading frame which could encode a light (L) chain-like protein with a molecular weight of 23,045. Our analysis suggests that two transcripts may be produced from the Ig lambda 1 gene that share the same Ig lambda 1 constant region- containing third exon. One transcript would include all three 14.1- related exons and be expressed from the germline gene, and the second transcript would be produced after variable-joining (V-J) recombination has occurred to Ig lambda J1 and would encode a classic Ig lambda L chain protein. The conservation of the genomic organization of the human 14.1 and Ig lambda 1 genes and the mouse homolog, lambda 5, relative to the classic Ig lambda L chain genes provides insight into the evolution of Ig genes.
机译：在B前细胞中，免疫球蛋白mu（Ig mu）与B前细胞特异性蛋白结合形成在细胞表面发现的多聚体复合物。这些蛋白质之一由三个外显子Ig lambda样基因14.1编码，其表达仅限于pre-B细胞，且发生于未重排的基因。 14.1基因结构与七基因人Igλ基因座的比较显示，最5'基因Igλ1的三外显子结构非常类似于14.1基因。这些三个外显子序列的转录和剪接将产生具有可读框的mRNA，该可读框可以编码分子量为23045的轻（L）链状蛋白。我们的分析表明，可能会从具有相同的含Ig lambda 1恒定区的第三外显子的Ig lambda 1基因产生两个转录本。一个转录本将包括所有三个与14.1相关的外显子，并从种系基因表达;第二个转录本将在Ig lambda J1发生可变连接（V-J）重组后产生，并编码经典Ig lambda L链蛋白。相对于经典的Ig lambda L链基因，人14.1和Ig lambda 1基因和小鼠同源物lambda 5的基因组组织的保守性提供了对Ig基因进化的洞察力。

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