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Effects of Acupuncture at GV20 and ST36 on the Expression of Matrix Metalloproteinase 2 Aquaporin 4 and Aquaporin 9 in Rats Subjected to Cerebral Ischemia/Reperfusion Injury

机译：针刺GV20和ST36对脑缺血再灌注损伤大鼠基质金属蛋白酶2水通道蛋白4和水通道蛋白9表达的影响。

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Background/PurposeIschemic stroke is characterized by high morbidity and mortality worldwide. Matrix metalloproteinase 2 (MMP2), aquaporin (AQP) 4, and AQP9 are linked to permeabilization of the blood-brain barrier (BBB) in cerebral ischemia/reperfusion injury (CIRI). BBB disruption, tissue inflammation, and MMP/AQP upregulation jointly provoke brain edema/swelling after CIRI, while acupuncture and electroacupuncture can alleviate CIRI symptoms. This study evaluated the hypothesis that acupuncture and electroacupuncture can similarly exert neuroprotective actions in a rat model of middle cerebral artery occlusion (MCAO) by modulating MMP2/AQP4/APQ9 expression and inflammatory cell infiltration.

机译：背景/目的缺血性中风的特征是全世界的高发病率和高死亡率。基质金属蛋白酶2（MMP2），水通道蛋白（AQP）4和AQP9与脑缺血/再灌注损伤（CIRI）中血脑屏障（BBB）的透化有关。 BBB破坏，组织炎症和MMP / AQP上调共同导致CIRI后脑水肿/肿胀，而针灸和电针可缓解CIRI症状。这项研究评估了以下假设：针刺和电针刺可通过调节MMP2 / AQP4 / APQ9表达和炎性细胞浸润在大鼠大脑中动脉闭塞（MCAO）模型中同样发挥神经保护作用。

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期刊名称 other
作者
Hong Xu; Yamin Zhang; Hua Sun; Suhui Chen; Fuming Wang;
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年(卷),期 -1(9),5
年度 -1
页码 e97488
总页数 10
原文格式 PDF
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1. Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury [J] . Ji Feng-Tao, Liang Jian-Jun, Miao Li-Ping, Molecular medicine reports . 2015,第2aPta2期

机译：异丙酚后处理可通过减少基质金属蛋白酶9和水通道蛋白4的表达来保护血脑屏障，并改善局灶性脑缺血再灌注损伤大鼠模型的神经行为结果
2. Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury [J] . Ji Feng-Tao, Liang Jian-Jun, Miao Li-Ping, Molecular medicine reports . 2015,第2aPta1期

机译：异丙酚后调节通过降低基质金属蛋白酶-9和水素-4表达来保护血脑屏障，并改善局灶性脑缺血再灌注损伤大鼠模型中的神经兽性结果
3. Resveratrol ameliorates oxidative stress and inhibits aquaporin 4 expression following rat cerebral ischemia-reperfusion injury [J] . Li Weina, Tan Changhong, Liu Yi, Molecular medicine reports . 2015,第5aPta2期

机译：白藜芦醇改善大鼠脑缺血-再灌注损伤后的氧化应激并抑制水通道蛋白4的表达
4. Effects of deferoxamine on the levels of matrix metalloproteinase-3 and the blood-brain barrier after cerebral ischemia reperfusion in rats [C] . Meng Meng, Jiang Wu, Yi Yang, International Conference on Human Health and Medical Engineering. . 2014

机译：Deferoxamine对大鼠脑缺血再灌注后基质金属蛋白酶-3和血脑屏障水平的影响
5. Role of matrix metalloproteinases in mediating myocardial injury during ischemia /reperfusion [D] . Romero-Perez, Diego 2008

机译：基质金属蛋白酶在介导缺血/再灌注期间心肌损伤中的作用
6. Electroacupuncture-Like Stimulation at the Baihui (GV20) and Dazhui (GV14) Acupoints Protects Rats against Subacute-Phase Cerebral Ischemia-Reperfusion Injuries by Reducing S100B-Mediated Neurotoxicity [O] . Chin-Yi Cheng, Jaung-Geng Lin, Nou-Ying Tang, -1

机译：在白辉（GV20）和大椎（GV14）穴位进行电针刺激通过减少S100B介导的神经毒性来保护大鼠免受亚急性期脑缺血再灌注损伤。
7. Effects of acupuncture at GV20 and ST36 on the expression of matrix metalloproteinase 2, aquaporin 4, and aquaporin 9 in rats subjected to cerebral ischemia/reperfusion injury. [O] . Hong Xu, Yamin Zhang, Hua Sun, 2014

机译：针刺GV20和sT36对脑缺血再灌注损伤大鼠基质金属蛋白酶2，水通道蛋白4和水通道蛋白9表达的影响。

Effects of Acupuncture at GV20 and ST36 on the Expression of Matrix Metalloproteinase 2 Aquaporin 4 and Aquaporin 9 in Rats Subjected to Cerebral Ischemia/Reperfusion Injury

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