• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Associations of HLA-A HLA-B and HLA-C Alleles Frequency with Prevalence of Herpes Simplex Virus Infections and Diseases Across Global Populations: Implication for the Development of an Universal CD8+ T-Cell Epitope-Based Vaccine
【2h】

Associations of HLA-A HLA-B and HLA-C Alleles Frequency with Prevalence of Herpes Simplex Virus Infections and Diseases Across Global Populations: Implication for the Development of an Universal CD8+ T-Cell Epitope-Based Vaccine

机译：HLA-AHLA-B和HLA-C等位基因频率与全球人群单纯疱疹病毒感染和疾病患病率的关联：对基于CD8 + T细胞抗原决定簇的通用疫苗开发的意义

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A significant portion of the world’s population is infected with herpes simplex virus type 1 and/or type 2 (HSV-1 and/or HSV-2), that cause a wide range of diseases including genital herpes, oro-facial herpes, and the potentially blinding ocular herpes. While the global prevalence and distribution of HSV-1 and HSV-2 infections cannot be exactly established, the general trends indicate that: (i) HSV-1 infections are much more prevalent globally than HSV-2; (ii) Over half billion people worldwide are infected with HSV-2; (iii) the sub-Saharan African populations account for a disproportionate burden of genital herpes infections and diseases; (iv) the dramatic differences in the prevalence of herpes infections between regions of the world appear to be associated with differences in the frequencies of human leukocyte antigen (HLA) alleles. The present report: (i) analyzes the prevalence of HSV-1 and HSV-2 infections across various regions of the world; (ii) analyzes potential associations of common HLA-A, HLA-B and HLA-C alleles with the prevalence of HSV-1 and HSV-2 infections in the Caucasoid, Oriental, Hispanic and Black major populations; and (iii) discusses how our recently developed HLA-A, HLA-B, and HLA-C transgenic/H-2 class I null mice will help validate HLA/herpes prevalence associations. Overall, high prevalence of herpes infection and disease appears to be associated with high frequency of HLA-A*24, HLA-B*27, HLA-B*53 and HLA-B*58 alleles. In contrast, low prevalence of herpes infection and disease appears to be associated with high frequency of HLA-B*44 allele. The finding will aid in developing a T-cell epitope-based universal herpes vaccine and immunotherapy.
机译：世界人口的很大一部分都感染了1型和/或2型单纯疱疹病毒（HSV-1和/或HSV-2），这些病毒引起多种疾病，包括生殖器疱疹，口面部疱疹和可能使眼疱疹致盲。虽然无法确切确定HSV-1和HSV-2感染的全球流行率和分布，但总体趋势表明：（i）HSV-1感染在全球范围内比HSV-2流行得多； （ii）全世界有超过五亿人感染了HSV-2； （iii）撒哈拉以南非洲人口造成生殖器疱疹感染和疾病的负担过大； （iv）世界各地之间疱疹感染率的巨大差异似乎与人类白细胞抗原（HLA）等位基因频率的差异有关。本报告：（一）分析了世界各地HSV-1和HSV-2感染的流行情况； （ii）分析高加索人，东方人，西班牙人和黑人主要人群中常见的HLA-A，HLA-B和HLA-C等位基因与HSV-1和HSV-2感染的患病率之间的潜在关联； （iii）讨论我们最近开发的HLA-A，HLA-B和HLA-C转基因/ H-2 I类零基因小鼠如何帮助验证HLA /疱疹患病率关联。总体而言，疱疹感染和疾病的高流行似乎与高频率的HLA-A * 24，HLA-B * 27，HLA-B * 53和HLA-B * 58等位基因相关。相反，疱疹感染和疾病的低流行似乎与HLA-B * 44等位基因的高频率有关。该发现将有助于开发基于T细胞表位的通用疱疹疫苗和免疫疗法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号