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Reduced risk of hypoglycemia with once-daily glargine versus twice-daily NPH and number needed to harm with NPH to demonstrate the risk of one additional hypoglycemic event in type 2 diabetes: Evidence from a long-term controlled trial

机译：每天一次甘精胰岛素与每天两次NPH相比降低了低血糖的风险并证明了损害NPH所需的数量可以证明2型糖尿病又发生一次降血糖事件的风险：一项长期对照试验的证据

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AimsThis analysis evaluated HbA1c-adjusted hypoglycemia risk with glargine versus neutral protamine Hagedorn (NPH) over a 5-year study in patients with Type 2 diabetes mellitus (T2DM). Clinical significance was assessed using number needed to harm (NNH) to demonstrate the risk of one additional patient experiencing at least one hypoglycemic event.

机译：目的这项分析在为期2年的2型糖尿病（T2DM）患者中进行了一项为期5年的研究，评估了甘精胰岛素与中性鱼精蛋白Hagedorn（NPH）联合HbA1c调整的低血糖风险。使用需要伤害的数字（NNH）评估临床意义，以证明另一名患者发生至少一项降血糖事件的风险。

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期刊名称 other
作者
Julio Rosenstock; Vivian Fonseca; Stefan Schinzel; Marie-Paule Dain; Peter Mullins; Matthew Riddle;
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作者单位

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年(卷),期 -1(28),5
年度 -1
页码 742–749
总页数 18
原文格式 PDF
正文语种
中图分类
关键词
Clinical science and care Clinical diabetes Glargine NPH Hypoglycemia;

机译：临床科学与护理;临床糖尿病;甘精胰岛素;NPH;低血糖;

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1. Reduced risk of hypoglycemia with once-daily glargine versus twice-daily NPH and number needed to harm with NPH to demonstrate the risk of one additional hypoglycemic event in type 2 diabetes: Evidence from a long-term controlled trial [J] . RosenstockJ., FonsecaV., SchinzelS., Journal of diabetes and its complications . 2014,第5期

机译：每日一次甘精胰岛素与每天两次NPH相比降低了低血糖的风险，以及需要NPN损害的数量以证明2型糖尿病又发生另一次降血糖事件的风险：一项长期对照试验的证据
2. Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes. [J] . Rosenstock J, Dailey G, Massi Benedetti M, Diabetes care . 2005,第4期

机译：甘精胰岛素可降低低血糖风险：荟萃分析比较甘精胰岛素与人NPH胰岛素治疗2型糖尿病。
3. Premeal insulin lispro plus bedtime NPH or twice-daily NPH in patients with type 2 diabetes: acute postprandial and chronic effects on glycemic control and cardiovascular risk factors. [J] . Ceriello A, Del-Prato S, Bue-Valleskey J, Journal of diabetes and its complications . 2007,第1期

机译：2型糖尿病患者的餐前赖脯胰岛素加睡前NPH或每日两次NPH：餐后和慢性对血糖控制和心血管危险因素的急性影响。
4. Severe Hypoglycemia, Risk of Recurrent Events and Weight Gain on Insulin Therapy in Patients with Type 1 Diabetes Mellitus. [D] . Liu, Zhiwen. 2011

机译：1型糖尿病患者的严重低血糖症，复发事件的风险和胰岛素治疗的体重增加。
5. Impact of patient and treatment characteristics on glycemic control and hypoglycemia in patients with type 2 diabetes initiated to insulin glargine or NPH [O] . Francesca Porcellati, Jay Lin, Paola Lucidi, -1

机译：甘精胰岛素或NPH引发的2型糖尿病患者的病情和治疗特点对血糖控制和低血糖的影响
6. Reduced risk of hypoglycemia with once-daily glargine versus twice-daily NPH and number needed to harm with NPH to demonstrate the risk of one additional hypoglycemic event in type 2 diabetes: Evidence from a long-term controlled trial [O] . Rosenstock Julio, Fonseca Vivian, Schinzel Stefan, 2014

机译：每天一次甘精胰岛素与每天两次NPH相比降低了低血糖的风险，以及需要NPN损害的数字以证明2型糖尿病又发生一次降血糖事件的风险：一项长期对照试验的证据

Reduced risk of hypoglycemia with once-daily glargine versus twice-daily NPH and number needed to harm with NPH to demonstrate the risk of one additional hypoglycemic event in type 2 diabetes: Evidence from a long-term controlled trial

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