首页> 美国卫生研究院文献>other >Cardiomyocyte-Specific Expression of CRNK the C-terminal Domain of PYK2 Maintains Ventricular Function and Slows Ventricular Remodeling in a Mouse Model of Dilated Cardiomyopathy

【2h】

Cardiomyocyte-Specific Expression of CRNK the C-terminal Domain of PYK2 Maintains Ventricular Function and Slows Ventricular Remodeling in a Mouse Model of Dilated Cardiomyopathy

机译：CRNKPYK2的C末端域心肌细胞的特异性表达在扩张型心肌病小鼠模型中维持心室功能并减慢心室重塑

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

RationaleUp-regulation and activation of PYK2, a member of the FAK family of protein tyrosine kinases, is involved in the pathogenesis of left ventricular (LV) remodeling and heart failure (HF). PYK2 activation can be prevented by CRNK, the C-terminal domain of PYK2. We previously demonstrated that adenoviral-mediated CRNK gene transfer improved survival and LV function, and slowed LV remodeling in a rat model of coronary artery ligation-induced HF.

机译：FAK蛋白酪氨酸激酶家族成员PYK2的上调和激活与左心室（LV）重塑和心力衰竭（HF）的发病机理有关。 CRNK（PYK2的C末端结构域）可以阻止PYK2激活。我们以前证明腺病毒介导的CRNK基因转移改善了冠状动脉结扎诱导的HF大鼠模型的存活率和LV功能，并减慢了LV重塑。

著录项

期刊名称 other
作者
Yevgeniya E. Koshman; Miensheng Chu; Taehoon Kim; Olivia Kalmanson; Mariam Farjah; Mohit Kumar; William Lewis; David L. Geenen; Pieter de Tombe; Paul H. Goldspink; R. John Solaro; Allen M. Samarel;
展开▼
作者单位

展开▼
年(卷),期 -1(72),-1
年度 -1
页码 281–291
总页数 25
原文格式 PDF
正文语种
中图分类
关键词
Heart failure gene expression protein kinase C echocardiography focal adhesion kinase;

机译：心力衰竭;基因表达;蛋白激酶C;超声心动图;粘着斑激酶;

相似文献

外文文献
中文文献
专利

1. Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomvopathv [J] . Yevgeniya E. Koshman, Miensheng Chu, Taehoon Kim, Journal of Molecular and Cellular Cardiology . 2014,第Null期

机译：CRNK，PYK2的C末端域，心肌细胞特异性表达在扩张型心肌病小鼠模型中维持心室功能并减慢心室重塑
2. Marked improvement in left ventricular function and significant reverse left ventricular remodeling within 3 months of cardiac resynchronization therapy in patients with dilated cardiomyopathy. [J] . Funck RC, Koelsch S, Waldhans S, PACE: Pacing and clinical electrophysiology . 2005,第Suppla1期

机译：扩张型心肌病患者在进行心脏再同步治疗后的3个月内，左心室功能明显改善，左心室重构明显改善。
3. Evaluating the significance of left ventricular midwall fibrosis detected by late gadolinium enhancement imaging on left ventricular functional remodelling in dilated cardiomyopathy [J] . Upasana Tayal, Simon Newsome, Ricardo Wage, Journal of cardiovascular magnetic resonance : . 2016,第S1期

机译：评价晚期g增强成像检测到的左室中壁纤维化对扩张型心肌病左室功能重塑的意义
4. Left ventricular perfusion/function differences between ischemic and dilated cardiomyopathy assessed by SPECT myocardial imaging: visual and quantitative computer analysis [C] . J. Maksimovic, M. Vavlukis, I. Peovska, Internationao Congress and Exhibition . 2002

机译：SPECT心肌成像评估缺血性和扩张心肌病的左心室灌注/功能差异：视觉和定量计算机分析
5. Extracellular matrix remodeling: Potential mechanisms by which aldosterone blockade improves ventricular remodeling and function post myocardial infarction. [D] . Le, Jenny Wenyi. 2003

机译：细胞外基质重塑：醛固酮阻滞改善心肌梗死后心室重塑和功能的潜在机制。
6. Evaluating the significance of left ventricular midwall fibrosis detected by late gadolinium enhancement imaging on left ventricular functional remodelling in dilated cardiomyopathy [O] . Upasana Tayal, Simon Newsome, Ricardo Wage, 2016

机译：评价晚期late增强成像检测到的左室中壁纤维化对扩张型心肌病左室功能重塑的意义
7. Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy [O] . Yevgeniya E. Koshman, Miensheng Chu, Taehoon Kim, 2014

机译：CrNK的心肌细胞特异性表达，Pyk2的C末端结构域，保持心室功能，并在扩张心肌病的小鼠模型中减缓心室重塑

Cardiomyocyte-Specific Expression of CRNK the C-terminal Domain of PYK2 Maintains Ventricular Function and Slows Ventricular Remodeling in a Mouse Model of Dilated Cardiomyopathy

摘要

著录项

相似文献

相关主题

期刊订阅