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The Probabilistic Convolution Tree: Efficient Exact Bayesian Inference for Faster LC-MS/MS Protein Inference

机译:概率卷积树:高效的精确贝叶斯推断可加快LC-MS / MS蛋白推断

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摘要

Exact Bayesian inference can sometimes be performed efficiently for special cases where a function has commutative and associative symmetry of its inputs (called “causal independence”). For this reason, it is desirable to exploit such symmetry on big data sets. Here we present a method to exploit a general form of this symmetry on probabilistic adder nodes by transforming those probabilistic adder nodes into a probabilistic convolution tree with which dynamic programming computes exact probabilities. A substantial speedup is demonstrated using an illustration example that can arise when identifying splice forms with bottom-up mass spectrometry-based proteomics. On this example, even state-of-the-art exact inference algorithms require a runtime more than exponential in the number of splice forms considered. By using the probabilistic convolution tree, we reduce the runtime to and the space to where is the number of variables joined by an additive or cardinal operator. This approach, which can also be used with junction tree inference, is applicable to graphs with arbitrary dependency on counting variables or cardinalities and can be used on diverse problems and fields like forward error correcting codes, elemental decomposition, and spectral demixing. The approach also trivially generalizes to multiple dimensions.
机译:精确的贝叶斯推断有时可以在特殊情况下有效地执行,在特殊情况下,函数的输入具有可交换和关联对称性(称为“因果独立性”)。因此,希望在大数据集上利用这种对称性。在这里,我们提出一种通过将概率加法器节点转换为概率卷积树以利用动态编程计算精确概率的方法,在概率加法器节点上利用这种对称性的一般形式。使用基于基于自下而上的质谱分析的蛋白质组学鉴定接头形式时可能出现的插图示例,证明了显着的提速。在此示例中,即使是最先进的精确推理算法,所需要的运行时间也比所考虑的拼接形式数量要大得多。通过使用概率卷积树,我们将运行时间减少了,并将空间减少到了由加法运算符或基数运算符连接的变量数。这种方法也可以与结点树推理一起使用,适用于对计数变量或基数有任意依赖性的图,并且可以用于各种问题和领域,例如前向纠错码,元素分解和频谱分解。该方法还简单地推广到多个维度。

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    Oliver Serang;

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  • 年(卷),期 -1(9),3
  • 年度 -1
  • 页码 e91507
  • 总页数 15
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