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Shedding Light on the Controversy Surrounding the Temporal Decline in Human Sperm Counts: A Systematic Review

机译:围绕人类精子数量暂时减少的争议的观点:系统综述

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摘要

We systematically examined the evidence of declining sperm counts and the hypothesis that an increased exposure to environmental pollutants is responsible for such decline. Search engines, including PUBMED, MEDLINE, EMBASE, BIOSIS, and Cochrane library, were used to identify epidemiologic studies published from 1985 to 2013. We concluded that there is no enough evidence to confirm a worldwide decline in sperm counts. Also, there seems to be no scientific truth of a causative role for endocrine disruptors in the temporal decline of sperm production. Such assumptions are based on few meta-analyses and retrospective studies, while other well-conducted researches could not confirm these findings. We acknowledge that difficult-to-control confounding factors in the highly variable nature of semen, selection criteria, and comparability of populations from different time periods in secular-trend studies, the quality of laboratory methods for counting sperm, and apparently geographic variations in semen quality are the main issues that complicate the interpretation of the available evidence. Owing to the importance of this subject and the uncertainties still prevailing, there is a need not only for continuing monitoring of semen quality, reproductive hormones, and xenobiotics, but also for a better definition of fecundity.
机译:我们系统地检查了精子数量下降的证据,以及这种环境下降的假说。搜索引擎,包括PUBMED,MEDLINE,EMBASE,BIOSIS和Cochrane库,被用于识别从1985年到2013年发表的流行病学研究。我们得出的结论是,没有足够的证据证实全世界范围内精子数量的下降。而且,似乎没有科学的内在干扰因素在精子产生的暂时性下降中起因作用的科学真理。这样的假设是基于很少的荟萃分析和回顾性研究,而其他进行良好的研究无法证实这些发现。我们认识到,精液高度可变的性质,选择标准以及长期趋势研究中不同时期的人群可比性,精子计数实验室方法的质量以及精液的明显地理差异等因素难以控制质量是使现有证据解释复杂化的主要问题。由于该主题的重要性以及不确定性仍然普遍存在,因此不仅需要继续监测精液质量,生殖激素和异种生物,而且还需要更好地确定生育力。

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  • 期刊名称 other
  • 作者单位
  • 年(卷),期 -1(2014),-1
  • 年度 -1
  • 页码 365691
  • 总页数 9
  • 原文格式 PDF
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