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Windowed Correlation: A Suitable Tool for Providing Dynamic fMRI-Based Functional Connectivity Neurofeedback on Task Difficulty

机译:窗口相关:一种适合在任务难度上提供基于动态fMRI的功能连接神经反馈的合适工具

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摘要

The goal of neurofeedback training is to provide participants with relevant information on their ongoing brain processes in order to enable them to change these processes in a meaningful way. Under the assumption of an intrinsic brain-behavior link, neurofeedback can be a tool to guide a participant towards a desired behavioral state, such as a healthier state in the case of patients. Current research in clinical neuroscience regarding the most robust indicators of pathological brain processes in psychiatric and neurological disorders indicates that fMRI-based functional connectivity measures may be among the most important biomarkers of disease. The present study therefore investigated the general potential of providing fMRI neurofeedback based on functional correlations, computed from short-window time course data at the level of single task periods. The ability to detect subtle changes in task performance with block-wise functional connectivity measures was evaluated based on imaging data from healthy participants performing a simple motor task, which was systematically varied along two task dimensions representing two different aspects of task difficulty. The results demonstrate that fMRI-based functional connectivity measures may provide a better indicator for an increase in overall (motor) task difficulty than activation level-based measures. Windowed functional correlations thus seem to provide relevant and unique information regarding ongoing brain processes, which is not captured equally well by standard activation level-based neurofeedback measures. Functional connectivity markers, therefore, may indeed provide a valuable tool to enhance and monitor learning within an fMRI neurofeedback setup.
机译:神经反馈训练的目的是为参与者提供有关其进行中的大脑过程的相关信息,以使他们能够以有意义的方式改变这些过程。在固有的脑-行为联系的假设下,神经反馈可以是一种引导参与者达到期望的行为状态的工具,例如对于患者而言更健康的状态。临床神经科学中有关精神病和神经病中病理性脑过程最强劲指标的最新研究表明,基于功能磁共振成像的功能连接性措施可能是疾病最重要的生物标记之一。因此,本研究调查了基于功能相关性提供fMRI神经反馈的一般潜力,该功能性相关性是根据单个任务周期水平上的短时程数据计算得出的。基于执行简单运动任务的健康参与者的成像数据,评估了使用逐块功能连接性措施检测任务性能细微变化的能力,该数据沿代表任务难度两个不同方面的两个任务维度系统地变化。结果表明,与基于激活水平的措施相比,基于功能磁共振成像的功能连接性措施可能为总体(运动)任务难度的增加提供更好的指标。因此,窗口功能相关性似乎提供了有关正在进行的大脑过程的相关且独特的信息,而基于标准激活水平的神经反馈措施不能很好地捕获这种信息。因此,功能连接性标记确实可以提供有价值的工具,以增强和监视fMRI神经反馈设置内的学习。

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