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首页> 美国卫生研究院文献>other >Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats
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Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats

机译：635 nm低功率激光治疗不同功率密度日均剂量对正常和糖尿病大鼠开放性皮肤伤口愈合的影响

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Background and Objective. Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats. Materials and Methods. Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n = 24) and diabetic (n = 24) Sprague–Dawley rats. AlGaInP (635 nm, wavelength; 5 J/cm2, daily dose) was used to deliver power densities of 1, 5, and 15 mW/cm2 three times daily until euthanasia. Results. PMNL infiltration was lower in the irradiated groups (15 mW/cm2). The synthesis and organisation of collagen fibres were consecutively enhanced in the 5 mW/cm2 and 15 mW/cm2 groups compared to the others in nondiabetic rats. In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15 mW/cm2. A significant difference in the number of newly formed capillaries in the irradiated group (5, 15 mW/cm2) was recorded on day six after injury compared to the control group. Conclusion. LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres.
机译：背景和目标。尽管尚不了解低水平激光疗法（LLLT）的分子机制，但在临床医学和外科手术中对光疗的开发仍然引起了人们的极大兴趣。本研究调查了LLLT对正常和糖尿病大鼠开放性皮肤伤口愈合的影响。材料和方法。在成年非糖尿病（n = 24）和糖尿病（n = 24）的Sprague–Dawley大鼠中，在背侧进行了四轮全层皮肤伤口。 AlGaInP（635 nm，波长； 5 J / cm 2 ，日剂量）用于每天三次提供1、5和15 mW / cm 2 的功率密度直到安乐死。结果。辐照组的PMNL渗透率较低（15μmW/ cm 2 ）。与非糖尿病大鼠相比，在5 mW / cm 2 和15 mW / cm 2 组中，胶原纤维的合成和组织连续增强。在糖尿病组中，唯一的显着差异是PMNL / Ma比为15 2 。与对照组相比，在损伤后第6天，受辐照组新生毛细血管的数量有明显差异（5，15μmW/ cm 2 ）。结论。 LLLT对过度的炎症组织反应具有保护作用；它刺激新血管形成和胶原纤维的早期形成。

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