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首页> 美国卫生研究院文献>other >Glottic Regeneration with Tissue Engineering Technique Using Acellular Extracellular Matrix Scaffold in Canine Model
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Glottic Regeneration with Tissue Engineering Technique Using Acellular Extracellular Matrix Scaffold in Canine Model

机译：脱细胞细胞外基质支架组织工程技术在犬模型中的声门再生。

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Acellular extracellular matrix scaffold derived from porcine urinary bladder (UBM) is decellularized material that has shown success for constructive remodeling of various tissues and organs. The regenerative effects of UBM were reported for the tympanic membrane, esophagus, trachea, larynx, pleura, and pericardium in animal studies with promising results. The aim of this study was to investigate regenerative effects of UBM to regenerate hemilarynx using a canine model. A left partial hemilaryngectomy was performed, and the surgical defects were reconstructed by insertion of UBM scaffold. Although local infection was observed in one dog in a week after implantation of the scaffold, all dogs showed good re-epithelialization with minimum complication in one month. The effect of regeneration of the larynx was evaluated 6 months after the operation. The excised larynx experiments were performed to measure phonation threshold pressure (PTP), normalized mucosal wave amplitude (NMWA), and normalized glottal gap (NGG). The results of the measurements showed that PTP was normal or near normal in 2 cases, NMWA was within normal range in 3 cases, although there were individual variations. Histologic examination was completed to evaluate structural changes of the scaffold with appearance of new cartilaginous structure. However the regenerated vocal fold mucosa is mostly scarred. The UBM scaffold has shown to be biocompatible, biodegradable, and useful for tissue regeneration of the hemilarynx with possible restoration of the vocal fold function. The vocal fold mucosa was scarred, which is the next challenge to improve.
机译：源自猪膀胱（UBM）的脱细胞细胞外基质支架是脱细胞材料，已显示出对各种组织和器官的建设性重塑的成功。据报道，在动物研究中，UBM对鼓膜，食道，气管，喉，胸膜和心包膜的再生作用具有可喜的结果。这项研究的目的是调查使用犬科动物模型UBM再生hemilnx的再生作用。进行左半部分喉切除术，并通过插入UBM支架重建手术缺损。尽管在植入支架后一周内在一只狗中观察到局部感染，但所有狗在一个月内均表现出良好的再上皮形成，且并发症最少。术后6个月评估喉的再生效果。进行切除的喉部实验以测量发声阈值压力（PTP），归一化粘膜波振幅（NMWA）和归一化声门间隙（NGG）。测量结果表明，PTP正常或接近正常2例，NMWA在正常范围内3例，尽管存在个体差异。完成组织学检查以评估支架的结构变化以及新的软骨结构的外观。然而，再生的声带粘膜大部分是疤痕状的。 UBM支架已显示出生物相容性，可生物降解性，可用于耳咽的组织再生，并可能恢复声带功能。声带粘膜瘢痕形成，这是下一个要改善的挑战。

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