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首页> 美国卫生研究院文献>other >Antidepressant Class Age and the Risk of Deliberate Self-Harm: A Propensity Score Matched Cohort Study of SSRI and SNRI Users in the US
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Antidepressant Class Age and the Risk of Deliberate Self-Harm: A Propensity Score Matched Cohort Study of SSRI and SNRI Users in the US

机译：抗抑郁药的类别年龄和故意自我伤害的风险：美国SSRI和SNRI用户的倾向得分匹配队列研究

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BackgroundThe US Food and Drug Administration’s meta-analyses of placebo-controlled antidepressant trials found approximately twice the rate of suicidal behaviors among children and adults 24 years of age and younger who were randomized to receive antidepressant medication, compared with those who were randomized to placebo. Rates of suicidal behavior were similar for subjects 25 to 64 years of age whether they received antidepressants or placebo, and subjects 65 years of age or older randomized to antidepressants were found to have lower rates of suicidal behavior. Age stratified FDA meta-analyses did not have adequate power to investigate rates of suicidal behaviors by antidepressant drug class.
机译：背景资料美国食品药物管理局对安慰剂对照抗抑郁药试验的荟萃分析发现，随机接受抗抑郁药治疗的24岁以下儿童和成年人的自杀行为发生率约为随机安慰剂对照者的两倍。无论是否接受抗抑郁药或安慰剂，年龄在25至64岁之间的受试者的自杀行为发生率均相似，而随机分配给抗抑郁药的65岁或65岁以上的受试者自杀行为发生率较低。年龄分层的FDA荟萃分析没有足够的能力来研究按抗抑郁药类别划分的自杀行为发生率。

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