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首页> 美国卫生研究院文献>The Journal of Experimental Medicine >Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s
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Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

机译：1型T辅助细胞（Th1s）和Th2s趋化因子受体的差异表达和趋化性

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T helper cells type 1 (Th1s) that produce interferon-γ predominantly mediate cellular immune responses and are involved in the development of chronic inflammatory conditions, whereas Th2s which produce large amounts of IL-4 and IL-5 upregulate IgE production and are prominent in the pathogenesis of allergic diseases. The precise factors determining whether Th1- or Th2-mediated immune responses preferentially occur at a peripheral site of antigen exposure are largely unknown. Chemokines, a superfamily of polypeptide mediators, are a key component of the leukocyte recruitment process. Here we report that among four CXC (CXCR1-4) and five CC (CCR1-5) chemokine receptors analyzed, CXCR3 and CCR5 are preferentially expressed in human Th1s. In contrast, Th2s preferentially express CCR4 and, to a lesser extent, CCR3. In agreement with the differential chemokine receptor expression, Th1s and Th2s selectively migrate in response to the corresponding chemokines. The differential expression of chemokine receptors may dictate, to a large extent, the migration and tissue homing of Th1s and Th2s. It may also determine different susceptibility of Th1s and Th2s to human immunodeficiency virus strains using different fusion coreceptors.
机译：产生干扰素-γ的1型T辅助细胞（Th1s）主要介导细胞免疫反应并参与慢性炎症性疾病的发展，而产生大量IL-4和IL-5的Th2s上调IgE的产生并在过敏性疾病的发病机理。确定Th1或Th2介导的免疫反应优先发生在抗原暴露的外围部位的确切因素在很大程度上未知。趋化因子是多肽介体的超家族，是白细胞募集过程的关键组成部分。在这里，我们报告分析的四个CXC（CXCR1-4）和五个CC（CCR1-5）趋化因子受体中，CXCR3和CCR5在人Th1s中优先表达。相反，Th2优先表达CCR4，而在较小程度上表达CCR3。与不同的趋化因子受体表达相一致，Th1和Th2s响应相应的趋化因子而选择性迁移。趋化因子受体的差异表达可能在很大程度上决定了Th1s和Th2s的迁移和组织归巢。它还可能使用不同的融合共受体来确定Th1和Th2对人免疫缺陷病毒株的敏感性。

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