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Gentian Violet: A 19th Century Drug Re-Emerges in the 21st Century

机译:龙胆紫:19世纪的毒品在21世纪重新出现

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摘要

Gentian violet (GV) has a long and varied history as a medicinal agent. Historically used as an anti-bacterial and anti-fungal, recent reports have shown its utility as an anti-typranosomal, anti-viral and anti-angiogenic agent. The objective of this paper is to summarize evidence regarding the efficacy, and safety of GV use in dermatology. Recent discoveries have found novel targets of GV, namely NADPH oxidase in mammalian cells and thioredoxin reductase 2 in bacterial, fungal, and parasitic cells. These discoveries have expanded the use of GV in the 21st century. Given that GV is well tolerated, effective and inexpensive, its use in dermatology is predicted to increase.
机译:龙胆紫(GV)作为药物的历史悠久且变化多端。从历史上用作抗菌和抗真菌剂,最近的报道表明其可用作抗typranosomal,抗病毒和抗血管生成剂。本文的目的是总结有关在皮肤病学中使用GV的功效和安全性的证据。最近的发现已经发现了GV的新靶标,即哺乳动物细胞中的NADPH氧化酶和细菌,真菌和寄生虫细胞中的硫氧还蛋白还原酶2。这些发现扩大了21世纪 世纪GV的使用。鉴于GV具有良好的耐受性,有效且价格低廉,预计在皮肤病学中的使用量会增加。

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