• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Extensive vascular remodeling in the spinal cord of pre-symptomatic experimental autoimmune encephalomyelitis mice; increased vessel expression of fibronectin and the α5β1 integrin
【2h】

Extensive vascular remodeling in the spinal cord of pre-symptomatic experimental autoimmune encephalomyelitis mice; increased vessel expression of fibronectin and the α5β1 integrin

机译：有症状的实验性自身免疫性脑脊髓炎小鼠的脊髓广泛血管重塑；纤连蛋白和α5β1整合素的血管表达增加

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alterations in vascular structure and function are a central component of demyelinating disease. In addition to blood-brain barrier (BBB) breakdown, which occurs early in the course of disease, recent studies have described angiogenic remodeling, both in multiple sclerosis tissue and in the mouse demyelinating model, experimental autoimmune encephalomyelitis (EAE). As the precise timing of vascular remodeling in demyelinating disease has yet to be fully defined, the purpose of the current study was to define the time-course of these events in the MOG35-55 EAE model. Quantification of endothelial cell proliferation and vessel density revealed that a large part of angiogenic remodeling in cervical spinal cord white matter occurs during the pre-symptomatic phase of EAE. At the height of vascular remodeling, blood vessels in the cervical spinal cord showed strong transient upregulation of fibronectin and the α5β1 integrin. In vitro experiments revealed that α5 integrin inhibition reduced brain endothelial cell proliferation under inflammatory conditions. Interestingly, loss of vascular integrity was evident in all vessels during the first 4–7 days post-immunization, but after 14 days, was localized predominantly to venules. Taken together, our data demonstrate that extensive vascular remodeling occurs during the pre-symptomatic phase of EAE and point to a potential role for the fibronectin-α5β1 integrin interaction in promoting vascular remodeling during demyelinating disease.
机译：血管结构和功能的改变是脱髓鞘疾病的重要组成部分。除了在病程早期发生的血脑屏障（BBB）分解外，最近的研究还描述了多发性硬化组织和小鼠脱髓鞘模型中的血管生成重塑，即实验性自身免疫性脑脊髓炎（EAE）。由于脱髓鞘疾病中血管重塑的确切时机尚未完全确定，本研究的目的是在MOG35-55 EAE模型中确定这些事件的时程。内皮细胞增殖和血管密度的量化显示，在颈脊髓白质中大部分血管生成重塑发生在EAE的症状前期。在血管重塑的高度，颈脊髓中的血管显示了纤连蛋白和α5β1整联蛋白的强烈瞬时上调。体外实验表明，α5整合素抑制作用在炎性条件下降低了脑内皮细胞的增殖。有趣的是，在免疫后的前4至7天，所有血管的血管完整性都明显下降，但14天后，主要定位在小静脉。两者合计，我们的数据表明广泛的血管重塑发生在EAE的症状前期，并指出纤连蛋白-α5β1整合素相互作用在脱髓鞘疾病期间促进血管重塑的潜在作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号