• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Oviduct Infection and Hydrosalpinx in DBA1/j Mice Is Induced by Intracervical but Not Intravaginal Inoculation with Chlamydia muridarum
【2h】

Oviduct Infection and Hydrosalpinx in DBA1/j Mice Is Induced by Intracervical but Not Intravaginal Inoculation with Chlamydia muridarum

机译：腹膜内感染而不是阴道衣原体诱导DBA1 / j小鼠输卵管感染和输卵管积水。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intravaginal infection with C. muridarum in mice often results in hydrosalpinx similar to that found in women urogenitally infected with C. trachomatis, making the C. muridarum lower genital tract infection murine model suitable for studying C. trachomatis pathogenesis. To our surprise, DBA1/j mice were highly resistant to hydrosalpinx following an intravaginal infection with C. muridarum although these mice were as susceptible to lower genital tract infection as other mouse strains. A significantly lower level of C. muridarum organisms was recovered from the oviduct of DBA1/j mice, correlating the resistance to hydrosalpinx with reduced ascension of C. muridarum to the oviduct. The DBA1/j resistance to hydrosalpinx was effectively overcome by intracervical inoculation with C. muridarum. The intracervically inoculated DBA1/j mice developed severe hydrosalpinx with the highest levels of live C. muridarum organisms recovered from uterine tissue on day 3 and oviduct tissue on day 7 post inoculation while in intravaginally inoculated DBA1/j mice, the peak of live organism recovery from uterine tissue was delayed to day 7 with no rise in the amount of live organisms recovered from the oviduct. These observations have not only validated the correlation between hydrosalpinx and live organism invasion in the oviduct but also demonstrated that the intracervical inoculation, by promoting rapid chlamydial replication in the uterine epithelial cells and ascension to the oviduct of DBA1/j mice, may be used for further understanding chlamydial pathogenic mechanisms. The above findings also suggest that strategies aimed at reducing tubal infection may be most effective in blocking tubal pathology.
机译：在小鼠的阴道内感染muridarum，通常会导致输卵管积水，与泌尿生殖道沙眼衣原体感染的女性相似，这使得muridarum生殖器官下生殖道感染的小鼠模型适合研究沙眼衣原体的发病机理。令我们惊讶的是，DBA1 / j小鼠在阴道内感染了破壁衣原体后对水salpinx具有高度抗性，尽管这些小鼠与其他小鼠品系一样易受下生殖道感染的影响。从DBA1 / j小鼠的输卵管中回收到了明显较低水平的Mur。muridarum微生物，这与对水刺沙门氏菌的抗性与muridarum对输卵管的上升降低相关。 DBA1 / j对hydrosalpinx的抵抗力可以通过腹腔内接种muridarum C.而得到有效克服。接种了神经胶质瘤的DBA1 / j小鼠出现了严重的输卵管积水，并具有最高水平的活的 C。在接种后第3天从子宫组织中回收到了muridarum 生物，在接种后第7天从输卵管中回收了卵，而在阴道内接种的DBA1 / j小鼠中，从子宫组织中回收的活生物体的峰值推迟到了第7天，没有从输卵管中回收的活生物体数量增加。这些观察结果不仅验证了输卵管积水与输卵管中活生物体入侵之间的相关性，而且还表明，通过促进子宫上皮细胞中衣原体的快速复制和提升至DBA1 / j小鼠的输卵管，可以进行脑内接种。进一步了解衣原体的致病机制。上述发现还表明，旨在减少输卵管感染的策略在阻断输卵管病理方面可能最有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号