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A Flexible Model for the Mean and Variance Functions with Application to Medical Cost Data

机译：均值和方差函数的灵活模型应用于医疗费用数据

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摘要

Medical cost data are often skewed to the right and heteroscedastic, having a nonlinear relation with covariates. To tackle these issues, we consider an extension to generalized linear models by assuming nonlinear associations of covariates in the mean function and allowing the variance to be an unknown but smooth function of the mean. We make no further assumption on the distributional form. The unknown functions are described by penalized splines, and the estimation is carried out using nonparametric quasi-likelihood. Simulation studies show the flexibility and advantages of our approach. We apply the model to the annual medical costs of heart failure patients in the clinical data repository (CDR) at the University of Virginia Hospital System.

机译：医疗费用数据通常偏向右侧且是异方差的，与协变量具有非线性关系。为了解决这些问题，我们考虑通过假设均值函数中协变量的非线性关联并使方差成为均值的未知但平滑函数来扩展到广义线性模型。我们对分布形式不做进一步的假设。用罚样条描述未知函数，并使用非参数拟似然来进行估计。仿真研究表明了我们方法的灵活性和优势。我们将该模型应用于弗吉尼亚大学医院系统临床数据存储库（CDR）中的心力衰竭患者的年度医疗费用。

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期刊名称 other
作者
Jinsong Chen; Lei Liu; Daowen Zhang; Ya-Chen T. Shih;
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作者单位

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年(卷),期 -1(32),24
年度 -1
页码 4306–4318
总页数 22
原文格式 PDF
正文语种
中图分类
关键词
Generalized linear model semiparametric regression health econometrics smoothing parameter generalized cross validation;

机译：广义线性模型;半参数回归;健康计量经济学;平滑参数;广义交叉验证;

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专利

1. A flexible model for the mean and variance functions, with application to medical cost data [J] . ChenJ., LiuL., ZhangD., Statistics in medicine . 2013,第24期

机译：均值和方差函数的灵活模型，适用于医疗费用数据
2. A flexible model for correlated medical costs, with application to medical expenditure panel survey data [J] . Chen Jinsong, Liu Lei, Shih Ya-Chen T., Statistics in medicine . 2016,第6期

机译：用于相关医疗费用的灵活模型，应用于医疗支出面板调查数据
3. A flexible quantile regression model for medical costs with application to Medical Expenditure Panel Survey Study [J] . Zhao Xiaobing, Wang Weiwei, Liu Lei, Statistics in medicine . 2018,第17期

机译：一种灵活的分位式回归模型，用于医疗支出面板调查研究
4. A Flexible Denormalization Technique for Data Analysis above a Deeply-Structured Relational Database: Biomedical Applications [C] . Stanislav Stefanic, Matej Lexa International Conference on Bioinformatics and Biomedical Engineering . 2015

机译：深度结构化关系数据库上方用于数据分析的灵活的非规范化技术：生物医学应用
5. Flexible mixed-effect modeling of functional data, with applications to process monitoring. [D] . Mosesova, Sofia A. 2007

机译：功能数据的灵活的混合效果建模，以及在过程监控中的应用。
6. A Flexible Model for Correlated Medical Costs with Application to Medical Expenditure Panel Survey Data [O] . Jinsong Chen, Lei Liu, Ya-Chen T. Shih, -1

机译：相关医疗费用的灵活模型应用于医疗支出面板调查数据
7. A flexible model for correlated medical costs, with application to medical expenditure panel survey data [O] . Jinsong Chen, Lei Liu, Ya-Chen T. Shih, 2015

机译：具有相关医疗成本的灵活模型，应用于医疗支出面板调查数据
8. Medical Logistics Functional Integration Management Activity Based Costing and Data Modeling Workshop. Volume 2. [R] . 1993

机译：基于医疗物流功能集成管理活动的成本核算与数据建模研讨会。第2卷。

A Flexible Model for the Mean and Variance Functions with Application to Medical Cost Data

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