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Harnessing CD4+ T cell responses in HIV vaccine development

机译:在HIV疫苗开发治理的CD4 + T细胞应答

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摘要

CD4+ T cells can perform a panoply of tasks to shape an effective response against a pathogen. Limited attention has been paid to the potential importance of functional CD4+ T cell responses in the context of the development of next-generation vaccines, including HIV vaccines. Many CD4+ T cell functions are newly appreciated and only partially understood. A workshop was held as a forum to bring together a small group of experts to exchange ideas on the role of CD4+ T cells in developing durable functional antibody responses, via follicular helper T cells, as well as on the roles of CD4+ T cells in other aspects of protective immunity. Here we discuss whether CD4+ T cell responses may represent a beneficial component of an efficacious HIV vaccine.
机译:CD4 + T细胞可以执行一系列任务,以形成针对病原体的有效反应。在开发下一代疫苗(包括HIV疫苗)的背景下,功能性CD4 + T细胞应答的潜在重要性受到了有限的关注。许多CD4 + T细胞功能受到新的重视,并且仅被部分理解。举办了一个研讨会作为论坛,以召集一小组专家通过滤泡辅助性T细胞以及CD4 + T细胞在发展持久性功能性抗体应答中的作用,以及CD4 + T细胞在保护性免疫的其他方面的作用在这里,我们讨论CD4 + T细胞应答是否可能代表有效的HIV疫苗的有益成分。

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