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A Quantitative Determination of Magnetic Nanoparticle SeparationUsing On-Off Field Operation of Quadrupole Magnetic Field-Flow Fractionation(QMgFFF)

机译:磁性纳米粒子分离的定量测定使用四极磁场流分馏的开关现场操作(QMGFFF)

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摘要

Quadrupole Magnetic Field-Flow Fractionation (QMgFFF) is a technique for characterization of sub-micrometer magnetic particles based on their retention in the magnetic field from flowing suspensions. Different magnetic field strengths and volumetric flow rates were tested using on-off field application and two commercial nanoparticle preparations that significantly differed in their retention parameter, λ (by nearly 8-fold). The fractograms showed a regular pattern of higher retention (98.6% v. 53.3%) for the larger particle (200 nm v. 90 nm) at the higher flow rate (0.05 mL/min v. 0.01 mL/min) at the highest magnetic field (0.52 T), as expected because of its lower retention parameter. The significance of this approach is a demonstration of a system that is simpler in operation than a programmed field QMgFFF in applications to particle mixtures consisting of two distinct particle fractions. This approach could be useful for detection of unwanted particulate contaminants, especially important in industrial and biomedical applications.
机译:四极磁场流分馏(QMgFFF)是一种基于亚微米级磁性粒子在流动悬浮液中保留在磁场中的特性。使用开关磁场应用和两种商品化的纳米粒子制剂(其保留参数λ(相差近8倍))进行了测试,测试了不同的磁场强度和体积流速。碎片图显示了较大的颗粒(200 nm对90 nm)在较高的流速(0.05 mL / min对0.01 mL / min)下具有较高保留率(98.6%v。53.3%)的规则模式字段(0.52 T),如预期的那样,因为其保留参数较低。这种方法的重要性在于证明了该系统在应用到由两个不同的粒子部分组成的粒子混合物中时,其操作比编程的现场QMgFFF更为简单。该方法对于检测不需要的颗粒污染物可能有用,在工业和生物医学应用中尤其重要。

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