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Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight

机译：血清BDNF浓度显示出强劲的季节性变化及其与环境的日照量相关性

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Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands Study of Depression and Anxiety (NESDA). Analyses by month of sampling (monthly n’s >196) showed pronounced seasonal variation in serum BDNF concentrations (P<.0001) with increasing concentrations in the spring-summer period (standardized regression weight (ß) = 0.19, P<.0001) and decreasing concentrations in the autumn-winter period (ß = −0.17, P<.0001). Effect sizes [Cohen’s d] ranged from 0.27 to 0.66 for monthly significant differences. We found similar seasonal variation for both sexes and for persons with a DSM-IV depression diagnosis and healthy control subjects. In explorative analyses we found that the number of sunshine hours (a major trigger to entrain seasonality) in the week of blood withdrawal and the 10 weeks prior to this event positively correlated with serum BDNF concentrations (Pearson’s correlation coefficients ranged: 0.05 – 0.18) and this could partly explain the observed monthly variation. These results provide strong evidence that serum BDNF concentrations systematically vary over the year. This finding is important for our understanding of those factors that regulate BDNF expression and may provide novel avenues to understand seasonal dependent changes in behavior and illness such as depression. Finally, the findings reported here should be taken into account when designing and interpreting studies on BDNF.
机译：较早的发现显示出过程和行为的季节性，例如脑可塑性和抑郁，部分受脑源性神经营养因子（BDNF）调节。基于此，我们调查了参加荷兰抑郁与焦虑研究（NESDA）的2851人的血清BDNF浓度的季节性变化。每月抽样分析（n> 196）每月显示出血清BDNF浓度的明显季节性变化（P <.0001），并随着春夏季浓度的增加而变化（标准回归权重（ß）= 0.19，P <.0001）和秋冬季浓度降低（ß= -0.17，P <.0001）。每月明显差异的影响大小[Cohen d]在0.27至0.66之间。我们发现性别，患有DSM-IV抑郁症的诊断者和健康对照者的季节性变化相似。在探索性分析中，我们发现抽血当周和此事件发生前10周的日照小时数（诱使季节性的主要诱因）与血清BDNF浓度呈正相关（Pearson相关系数范围为0.05 – 0.18）和这可以部分解释观察到的每月变化。这些结果提供了有力的证据，证明血清BDNF的浓度在一年中有系统地变化。这一发现对我们理解调节BDNF表达的那些因素很重要，并且可能为理解行为和疾病（例如抑郁症）的季节性依赖变化提供新途径。最后，在设计和解释有关BDNF的研究时，应考虑此处报告的发现。

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