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Human Epididymis Protein 4 (HE4) is Upregulated in Gastric and Pancreatic Adenocarcinomas

机译：人物附睾蛋白4（HE4）在胃和胰腺腺癌中上调

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Upper gastrointestinal neoplasia in the esophagus, stomach and pancreas is associated with the formation of pre-neoplastic metaplasias. We have previously reported the up-regulation of Human epididymis protein 4 (HE4) in all metaplasias in the stomach of humans and mice. We have now sought to evaluate the expression of HE4 in metaplasias/pre-neoplastic precursors and cancers of the human stomach, pancreas and esophagus. Tissue microarrays for gastric cancers, pancreatic cancers and esophageal adenocarcinoma were stained with antibodies against HE4. Immunostaining was quantified by digital imaging and the results were evaluated to assess expression in metaplasias, expression in cancer pathological subtypes and the effects of expression on survival in cancer patients. In gastric cancer patients from Korea, HE4 was detected in 74% of intestinal and 90% of diffuse cancers, while in a gastric cancer cohort from Johns Hopkins HE4 was detected 74% of intestinal type and 92% of diffuse cancers. Nevertheless, in both cohorts there was no impact of HE4 expression on overall survival. In the esophagus, we observed expression of HE4 in scattered endocrine cells within Barrett’s esophagus samples, but Barrett’s columnar metaplasias and HE4 was detected in only 2% of esophageal adenocarcinomas. Finally, in the pancreas, HE4 expression was not observed in pancreatic intraepithelial neoplasia (PanIN) lesions, but 46.8% of pancreatic adenocarcinomas expressed HE4 expression. Still, we did not observe any influence of HE4 expression on survival. The results suggest that HE4 is up-regulated during gastric and pancreatic carcinogenesis.
机译：食道，胃和胰腺的上消化道肿瘤与肿瘤前的化生有关。我们以前曾报道过人类和小鼠的胃部所有化生中人类附睾蛋白4（HE4）的上调。现在，我们试图评估HE4在化生/肿瘤前期前体和人胃，胰腺和食道癌中的表达。用针对HE4的抗体对胃癌，胰腺癌和食管腺癌的组织芯片进行染色。通过数字成像对免疫染色进行定量，并对结果进行评估，以评估其在化生组织中的表达，在癌症病理亚型中的表达以及该表达对癌症患者生存的影响。在韩国的胃癌患者中，有74％的肠道和90％的弥漫性癌症中都检出了HE4，而约翰·霍普金斯大学的胃癌队列中，有74％的肠道类型和92％的弥漫性癌中检出了HE4。然而，在这两个队列中，HE4表达对总体存活率均没有影响。在食道中，我们观察到HE4在Barrett食道样本中的散乱的内分泌细胞中表达，但是Barrett的柱状化生和HE4仅在2％的食道腺癌中被检测到。最后，在胰腺中，在胰腺上皮内瘤变（PanIN）病变中未观察到HE4表达，但是46.8％的胰腺腺癌表达HE4表达。尽管如此，我们仍未观察到HE4表达对生存的任何影响。结果表明HE4在胃和胰腺癌发生过程中被上调。

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