• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Characterization of Cell Proliferation throughout the Brain of the African Cichlid Fish Astatotilapia burtoni and its Regulation by Social Status
【2h】

Characterization of Cell Proliferation throughout the Brain of the African Cichlid Fish Astatotilapia burtoni and its Regulation by Social Status

机译：非洲慈鲷鱼类大鼠Burtoni的脑中细胞增殖的特征及其社会地位监管

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

New cells are added in the brains of all adult vertebrates, but fishes have some of the greatest potential for neurogenesis and gliogenesis among all taxa, partly due to their indeterminate growth. Little is known, however, about how social interactions influence cell proliferation in the brain of these fishes that comprise the largest group of vertebrates. We used 5-bromo-2′-deoxy-uridine (BrdU) to identify and localize proliferation zones in the telencephalon, diencephalon, mesencephalon, and rhombencephalon that were primarily associated with ventricular surfaces in the brain of the African cichlid fish Astatotilapia burtoni. Cell migration was evident in some regions by 1 day post injection, and many newborn cells coexpressed the neuronal marker HuC/D at 30 days, suggesting they had differentiated into neurons. To test the hypothesis that social status and perception of an opportunity to rise in rank influenced cell proliferation, we compared numbers of BrdU-labeled cells in multiple brain nuclei among fish of different social status. Socially suppressed subordinate males had the lowest numbers of proliferating cells in all brain regions examined, but males that were given an opportunity to rise in status had higher cell proliferation rates within 1 day, suggesting rapid upregulation of brain mitotic activity associated with this social transition. Furthermore, socially isolated dominant males had similar numbers of BrdU-labeled cells compared with dominant males that were housed in a socially rich environment, suggesting that isolation has little effect on proliferation and that reduced proliferation in subordinates is a result of the social subordination. These results suggest that A. burtoni will be a useful model to analyze the mechanisms of socially induced neurogenesis in vertebrates.
机译：新细胞被添加到所有成年脊椎动物的大脑中，但是鱼类在所有类群中具有神经发生和神经胶质发生的最大潜力，部分原因是它们的生长不确定。然而，关于社交互动如何影响这些构成最大脊椎动物群体的鱼类的大脑细胞增殖的知之甚少。我们使用了5-溴-2'-脱氧尿苷（BrdU）来鉴定和定位端粒脑，间脑，中脑和菱脑的增殖区，这些增殖区主要与非洲丽鱼科鱼白纹线虫大脑的脑室表面有关。注射后1天，某些区域细胞迁移明显，许多新生细胞在30天时共表达神经元标记物HuC / D，表明它们已分化为神经元。为了检验社会地位和升职机会的感知影响细胞增殖这一假说，我们比较了不同社会地位的鱼类中多个脑核中BrdU标记的细胞数量。在所有受检查的大脑区域中，受到社会压制的从属男性的增殖细胞数量最少，但是，有地位提升机会的男性在1天之内具有较高的细胞增殖率，这表明与这种社会转型有关的脑有丝分裂活动迅速上调。此外，与社会上处于隔离状态的雄性相比，在社会上处于隔离状态的显性雄性具有数量与BrdU标记的细胞相似，这表明隔离对繁殖几乎没有影响，下属的繁殖减少是社会从属的结果。这些结果表明，伯顿曲霉将是一个有用的模型，用于分析脊椎动物中社会诱导的神经发生的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号