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首页> 美国卫生研究院文献>other >Synergism and Rules from Combination of Baicalin Jasminoidin and Desoxycholic acid in Refined Qing Kai Ling for Treat Ischemic Stroke Mice Model
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Synergism and Rules from Combination of Baicalin Jasminoidin and Desoxycholic acid in Refined Qing Kai Ling for Treat Ischemic Stroke Mice Model

机译：协同作用和规则从在精制清开灵黄芩苷栀子苷和脱氧胆酸结合用于治疗缺血性中风模型小鼠

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摘要

Refined Qing-Kai-Ling (QKL), a modified Chinese medicine, consists of three main ingredients (Baicalin, Jasminoidin and Desoxycholic acid), plays a synergistic effect on the treatment of the acute stage of ischemic stroke. However, the rules of the combination and synergism are still unknown. Based on the ischemic stroke mice model, all different kinds of combination of Baicalin, Jasminoidin, and Desoxycholic acid were investigated by the methods of neurological examination, microarray, and genomics analysis. As a result, it confirmed that the combination of three drugs offered a better therapeutical effect on ischemic stroke than monotherapy of each drug. Additionally, we used Ingenuity pathway Analysis (IPA) and principal component analysis (PCA) to extract the dominant information of expression changes in 373 ischemia-related genes. The results suggested that 5 principal components (PC1-5) could account for more than 95% energy in the gene data. Moreover, 3 clusters (PC1, PC2+PC5, and PC3+PC4) were addressed with cluster analysis. Furthermore, we matched PCs on the drug-target networks, the findings demonstrated that Baicalin related with PC1 that played the leading role in the combination; Jasminoidin related with PC2+PC5 that played a compensatory role; while Desoxycholic acid had the least performance alone which could relate with PC3+PC4 that played a compatible role. These manifestations were accorded with the principle of herbal formulae of Traditional Chinese Medicine (TCM), emperor-minister-adjuvant-courier. In conclusion, we firstly provided scientific evidence to the classic theory of TCM formulae, an initiating holistic viewpoint of combination therapy of TCM. This study also illustrated that PCA might be an applicable method to analyze the complicated data of drug combination.
机译：精制的庆开灵（QKL）是一种改良的中药，由三种主要成分（黄ical苷，茉莉素和去氧胆酸）组成，对缺血性中风的急性期具有协同作用。但是，结合和协同作用的规则仍然未知。在缺血性中风小鼠模型的基础上，通过神经学检查，微阵列和基因组学分析方法研究了黄ical苷，茉莉素和脱氧胆酸的各种不同组合。结果，证实了三种药物的组合对缺血性中风的治疗效果比每种药物的单一疗法更好。此外，我们使用了机能途径分析（IPA）和主成分分析（PCA）来提取373个缺血相关基因中表达变化的主要信息。结果表明，5个主要成分（PC1-5）可以占基因数据中95％以上的能量。此外，通过聚类分析解决了3个聚类（PC1，PC2 + PC5和PC3 + PC4）。此外，我们在药物靶向网络上匹配了PC，结果表明黄the苷与PC1相关，在组合中起主导作用；茉莉素与PC2 + PC5有关，起补偿作用。而脱氧胆酸仅具有最低的性能，可能与PC3 + PC4发挥了兼容作用。这些表现符合中医草药配方的原则，即皇帝-部长-佐剂-信使。综上所述，我们首先为经典的中医复方理论提供了科学依据，这是中医综合治疗的开端整体观点。这项研究还表明，PCA可能是分析药物组合复杂数据的一种适用方法。

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