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A voxel-based morphometry (VBM) analysis of regional grey and white matter volume abnormalities within the speech production network of children who stutter

机译：基于体文的形态学（VBM）分析口吃的儿童语音生产网络中的区域灰色和白质量异常分析

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It is well documented that neuroanatomical differences exist between adults who stutter and their fluently speaking peers. Specifically, adults who stutter have been found to have more grey matter volume (GMV) in speech relevant regions including inferior frontal gyrus, insula and superior temporal gyrus (; ). Despite stuttering having its onset in childhood only one study has investigated the neuroanatomical differences between children who do and do not stutter. reported children who stutter had less GMV in the bilateral inferior frontal gyri and middle temporal gyrus relative to fluently speaking children. Thus it appears that children who stutter present with unique neuroanatomical abnormalities as compared to those of adults who stutter. In order to better understand the neuroanatomical correlates of stuttering earlier in its development, near the time of onset, we used voxel-based morphometry to examine volumetric differences between 11 children who stutter and 11 fluent children. Children who stutter had less GMV in the bilateral inferior frontal gyri and left putamen but more GMV in right Rolandic operculum and superior temporal gyrus relative to fluent children. Children who stutter also had less white matter volume bilaterally in the forceps minor of the corpus callosum. We discuss our findings of widespread anatomic abnormalities throughout the cortical network for speech motor control within the context of the speech motor skill limitations identified in people who stutter (; ).
机译：有充分的文献证明，口吃的成年人和会说流利的同伴之间存在神经解剖学差异。具体来说，已经发现口吃的成年人在言语相关区域（包括额下回，岛状和颞上回（;））具有更高的灰质体积（GMV）。尽管口吃在儿童时期就已开始，但只有一项研究调查了患有和不患有口吃的儿童之间的神经解剖学差异。报道说，相对于说一口流利的儿童，口吃的儿童双侧下额回和中颞回的GMV较少。因此，与成人相比，口吃的儿童表现出独特的神经解剖学异常。为了更好地了解口吃的神经解剖学相关性，我们在发病时临近发病时，使用基于体素的形态计量技术检查了11位口吃的孩子和11位流利的孩子之间的体积差异。相对于流利的儿童，口吃的儿童双侧下额回和左壳核的GMV较少，但右罗兰特和颞上回的GMV较高。口吃的儿童在call体小镊子两侧的白质量也较少。我们讨论了在口吃的人发现的语音运动技能限制的情况下，整个皮质网络中用于语音运动控制的广泛解剖异常的发现。

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