首页> 美国卫生研究院文献>other >Enhanced glutamate uptake into synaptic vesicles fueled by vesicle-generated ATP from phosphoenolpyruvate and ADP. Proposed role of a novel enzyme

【2h】

Enhanced glutamate uptake into synaptic vesicles fueled by vesicle-generated ATP from phosphoenolpyruvate and ADP. Proposed role of a novel enzyme

机译：增强谷氨酸的摄取到来自磷酸溶胶和ADP的囊泡产生的ATP燃料的突触囊泡。提出了一种新型酶的作用

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Glycolytic ATP synthesis by synaptic vesicles provides an efficient mechanism for fueling vesicular loading of the neurotransmitter glutamate. This is achieved in part by vesicle-bound pyruvate kinase. However, we have found that vesicular glutamate uptake, in the presence of the pyruvate kinase substrates ADP and phosphoenolpyruvate (PEP), substantially exceeds that caused by exogenous ATP. We propose that this much enhanced uptake is in part due to extra ATP produced via a mechanism involving a novel enzyme, PEP-dependent ADP synthase. We discuss implications for this enzyme in energy homeostasis and pathophysiology, as well as in efficient synaptic glutamate transmission.

机译：突触小泡的糖酵解ATP合成为神经递质谷氨酸的小泡负载提供了有效的机制。这部分地通过囊泡结合的丙酮酸激酶实现。然而，我们发现，在丙酮酸激酶底物ADP和磷酸烯醇丙酮酸（PEP）存在下，囊泡谷氨酸的摄取大大超过了外源ATP引起的摄取。我们提出，这种大大提高的摄取部分归因于通过涉及一种新型酶，PEP依赖性ADP合酶的机制产生的额外ATP。我们讨论了这种酶在能量稳态和病理生理以及有效的突触谷氨酸传递中的意义。

著录项

期刊名称 other
作者
Kouji Takeda; Tetsufumi Ueda;
展开▼
作者单位

展开▼
年(卷),期 -1(37),12
年度 -1
页码 2731–2737
总页数 16
原文格式 PDF
正文语种
中图分类
关键词
energy metabolism ADP synthesis glycolytic intermediate VGLUT glutamate transmission;

机译：能量代谢;ADP合成;糖酵解中间体;VGLUT;谷氨酸传递;

相似文献

外文文献
中文文献
专利

1. Enhanced glutamate uptake into synaptic vesicles fueled by vesicle-generated ATP from phosphoenolpyruvate and ADP: Proposed role of a novel enzyme [J] . TakedaK., UedaT. Neurochemical research . 2012,第12期

机译：由磷酸烯醇丙酮酸和ADP囊泡产生的ATP促进谷氨酸对突触囊泡的摄取：新型酶的拟议作用
2. Enhanced Glutamate Uptake into Synaptic Vesicles Fueled by Vesicle-generated ATP from Phosphoenolpyruvate and ADP [J] . Kouji Takeda, Tetsufumi Ueda Neurochemical Research . 2012,第12期

机译：磷酸烯醇丙酮酸和ADP囊泡产生的ATP促进了谷氨酸对突触囊泡的吸收
3. Transport of γ-aminobutyrate and l-glutamate into synaptic vesicles. Effect of different inhibitors on the vesicular uptake of neurotransmitters and on the Mg2+-ATPase [J] . E M Fykse, F Fonnum The biochemical journal . 1991,第2期

机译：γ-氨基丁酸酯和l-谷氨酸转运到突触小泡中。不同抑制剂对神经递质水泡摄取和Mg2 + -ATPase的影响
4. Bidirectional astrocyte-neuron communication: the many roles of glutamate and ATP [C] . Tommaso Fellin, Jai-Yoon Sul, Marcello DAscenzo, Symposium on Purinergic Signalling in Neuron-Glia Interactions . 2006

机译：双向星形织物 - 神经元通信：谷氨酸和ATP的许多角色
5. Impaired synaptic vesicle reformation in synaptojanin 1 knockout mice: Insights into the role of phosphoinositides in synaptic vesicle recycling. [D] . Kim, Warren Tackhoon. 2003

机译：Synaptojanin 1基因敲除小鼠的突触小泡再造受损：磷酸肌醇在突触小泡循环中的作用的见解。
6. Transport of gamma-aminobutyrate and L-glutamate into synaptic vesicles. Effect of different inhibitors on the vesicular uptake of neurotransmitters and on the Mg2(+)-ATPase. [O] . E M Fykse, F Fonnum 1991

机译：γ-氨基丁酸和L-谷氨酸转运到突触小泡中。不同抑制剂对神经递质水泡摄取和Mg2（+）-ATPase的影响。
7. Comparison of endogenous and exogenous sources of ATP in fueling Ca2+ uptake in smooth muscle plasma membrane vesicles [O] . 1992

机译：内源性和外源性ATP促进平滑肌质膜囊泡吸收Ca2 +的比较
8. Properties of the Uptake System for Glycine in Synaptic Vesicles [R] . Christensen, H. 1992

机译：突触小泡中甘氨酸摄取系统的特性

Enhanced glutamate uptake into synaptic vesicles fueled by vesicle-generated ATP from phosphoenolpyruvate and ADP. Proposed role of a novel enzyme

摘要

著录项

相似文献

相关主题

期刊订阅