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The Notch signalling system: recent insights into the complexity of a conserved pathway

机译：Notch信号系统：近期分析上市公司一个保守的途径的复杂性

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Notch signalling links the fate of one cell to that of an immediate neighbour and consequently controls differentiation, proliferation and apoptotic events in multiple metazoan tissues. Perturbations in this pathway activity have been linked to several human genetic disorders and cancers. Recent genome-scale studies in Drosophila melanogaster have revealed an extraordinarily complex network of genes that can affect Notch activity. This highly interconnected network contrasts our traditional view of the Notch pathway as a simple linear sequence of events. Although we now have an unprecedented insight into the way in which such a fundamental signalling mechanism is controlled by the genome, we are faced with serious challenges in analysing the underlying molecular mechanisms of Notch signal control.

机译：Notch信号将一个细胞的命运与直接邻居的命运联系起来，从而控制多个后生组织中的分化，增殖和凋亡事件。这种途径活动的扰动已与几种人类遗传疾病和癌症相关。最近在果蝇中进行的基因组规模研究表明，可能影响Notch活性的基因网络异常复杂。这种高度互连的网络将传统的Notch路径视为简单的线性事件序列形成了鲜明的对比。尽管我们现在对基因组控制这种基本信号传导机制的方式有了空前的见识，但在分析Notch信号控制的潜在分子机制时，我们仍面临着严峻的挑战。

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K. G. Guruharsha; Mark W. Kankel; Spyros Artavanis-Tsakonas;
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年(卷),期 -1(13),9
年度 -1
页码 654–666
总页数 30
原文格式 PDF
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1. The Notch signalling system: Recent insights into the complexity of a conserved pathway [J] . GuruharshaK.G., KankelM.W., Artavanis-TsakonasS. Nature reviews. Genetics . 2012,第9期

机译：Notch信号系统：对保守途径复杂性的最新见解
2. Competitive pressures affect sexual signal complexity in Kurixalus odontotarsus: insights into the evolution of compound calls Competitive pressures affect sexual signal complexity in Kurixalus odontotarsus: insights into the evolution of compound calls Competitive pressures affect sexual signal complexity in Kurixalus odontotarsus: insights into the evolution of compound calls [J] . Jichao Wang, Yue Yang, Jianguo Cui, Biology Open . 2017,第12期

机译：竞争压力影响齿尖嘴鸟的性信号复杂性：对复合呼叫进化的洞察力竞争压力影响齿尖嘴鸟的性信号复杂性：对复合呼叫进化的认识来电
3. An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning [J] . Elaine R. Reynolds, Ryan Himmelwright, Christopher Sanginiti, BMC Systems Biology . 2019,第1期

机译：Notch信号通路的基于代理的模型阐明了确定发育模式的三个复杂程度
4. Finding better partitions and conserved modules in Wnt signaling pathways [C] . L. Nayak, R. K. De International Conference on Bioinformatics and Computational Biology . 2012

机译：在WNT信令路径中找到更好的分区和保守模块
5. Protein microarray technology for profiling signaling pathways: Insights into pro-oncogenic Notch signaling in T cell acute lymphoblastic leukemia. [D] . Chan, Steven Man Cheong. 2006

机译：用于分析信号传导途径的蛋白质微阵列技术：洞悉促T细胞急性淋巴细胞白血病中促癌的Notch信号传导。
6. An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning [O] . Elaine R. Reynolds, Ryan Himmelwright, Christopher Sanginiti, 2019

机译：Notch信号通路的基于代理的模型阐明了确定发育模式的三个复杂程度
7. Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells [O] . Masuko Katoh, Masaru Katoh 2006

机译：Notch配体Jag1在祖细胞中的规范Wnt信号通路的进化靶标

The Notch signalling system: recent insights into the complexity of a conserved pathway

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