• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Magnetic Relaxometry with an Atomic Magnetometer and SQUID Sensors on Targeted Cancer Cells
【2h】

Magnetic Relaxometry with an Atomic Magnetometer and SQUID Sensors on Targeted Cancer Cells

机译：磁力磁力测定法与靶向癌细胞上的原子磁力计和鱿鱼传感器

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Magnetic relaxometry methods have been shown to be very sensitive in detecting cancer cells and other targeted diseases. Superconducting Quantum Interference Device (SQUID) sensors are one of the primary sensor systems used in this methodology because of their high sensitivity with demonstrated capabilities of detecting fewer than 100,000 magnetically-labeled cancer cells. The emerging technology of atomic magnetometers (AM) represents a new detection method for magnetic relaxometry with high sensitivity and without the requirement for cryogens. We report here on a study of magnetic relaxometry using both AM and SQUID sensors to detect cancer cells that are coated with superparamagnetic nanoparticles through antibody targeting. The AM studies conform closely to SQUID sensor results in the measurement of the magnetic decay characteristics following a magnetization pulse. The AM and SQUID sensor data are well described theoretically for superparamagnetic particles bound to cells and the results can be used to determine the number of cells in a cell culture or tumor. The observed fields and magnetic moments of cancer cells are linear with the number of cells over a very large range. The AM sensor demonstrates very high sensitivity for detecting magnetically labeled cells does not require cryogenic cooling and is relatively inexpensive.
机译：磁弛豫法已经显示出在检测癌细胞和其他目标疾病中非常敏感。超导量子干扰设备（SQUID）传感器是该方法中使用的主要传感器系统之一，因为它们具有很高的灵敏度，并具有检测少于100,000个磁性标记癌细胞的能力。原子磁强计（AM）的新兴技术代表了一种磁弛豫检测的新方法，该方法具有高灵敏度且不需要冷冻剂。我们在此报告有关使用AM和SQUID传感器进行磁弛豫测定的研究，以通过抗体靶向检测被超顺磁性纳米颗粒包覆的癌细胞。 AM研究与SQUID传感器结果非常吻合，可测量磁化脉冲后的磁衰减特性。对于与细胞结合的超顺磁性颗粒，AM和SQUID传感器数据在理论上得到了很好的描述，其结果可用于确定细胞培养物或肿瘤中的细胞数量。癌细胞的观测场和磁矩与很大范围内的细胞数量呈线性关系。 AM传感器显示出非常高的灵敏度，可检测磁性标记的细胞，无需低温冷却，并且相对便宜。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号