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首页> 美国卫生研究院文献>other >Analysis of Brain Metabolism by Proton-Magnetic-Resonance-Spectroscopy (1H-MRS) in Attention-Deficit/Hyperactivity Disorder Suggests a Generalized Differential Ontogenic Pattern from Controls
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Analysis of Brain Metabolism by Proton-Magnetic-Resonance-Spectroscopy (1H-MRS) in Attention-Deficit/Hyperactivity Disorder Suggests a Generalized Differential Ontogenic Pattern from Controls

机译：通过质子 - 磁共振 - 光谱（1H-MRS）在注意力缺陷/多动障碍中分析脑代谢的分析表明来自对照的广义差异化肿瘤

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Attention-deficit/hyperactivity disorder (ADHD) is the most common behavioral disorder of childhood. Preliminary studies with proton magnetic resonance spectroscopy (1HMRS) of the brain have reported differences in brain metabolite concentration-to-Cr ratios between individuals with ADHD and unaffected controls in several frontal brain regions including anterior cingulate cortex. Using multivoxel 1H-MRS, we compared 14 individuals affected with ADHD to 20 individuals without ADHD from the same genetic isolate. After controlling by sex, age and multiple testing, we found significant differences at the right posterior cingulate of the Glx/Cr ratio density distribution function between ADHD cases and controls (P<0.05). Furthermore, we found several interactions of metabolite concentration-to-Cr ratio, age, and ADHD status: Ins/Cr and Glx/Cr ratios at the left posterior cingulate, and NAA/Cr at the splenius, right posterior cingulate, and at the left posterior cingulate. We also found a differential metabolite ratio interaction between ADHD cases and controls for Ins/Cr and NAA/Cr at the right striatum. These results show that: 1) NAA/Cr, Glx/Cr and Ins/Cr ratios, as reported in other studies, exhibit significant differences between ADHD cases and controls; 2) differences of these metabolite ratios between ADHD cases and controls evolve in specific and recognizable patterns throughout age, a finding that replicates previous results obtained by structural MRI, where is demonstrated that brain ontogeny follows a different program in ADHD cases and controls; 3) Ins/Cr and NAA/Cr ratios, at the right striatum, interact in a differential way between ADHD cases and controls. As a whole, these results replicate previous 1H-MRS findings and add new intriguing differential metabolic and ontogeny patterns between ADHD cases and controls that warrant further pursue.
机译：注意缺陷/多动障碍（ADHD）是儿童最常见的行为障碍。大脑的质子磁共振波谱（1HMRS）的初步研究已经报告了ADHD个体与未受影响的对照组（包括前扣带回皮层）在多个前脑区域的大脑代谢物浓度/铬比。使用multivoxel 1H-MRS，我们比较了来自同一基因分离株的14位患有ADHD的个体与20位没有ADHD的个体。在按性别，年龄和多项测试进行控制后，我们发现ADHD病例与对照组之间Glx / Cr比密度分布函数的右后扣带有显着差异（P <0.05）。此外，我们发现了代谢物浓度与Cr的比率，年龄和ADHD状态的几种相互作用：左扣带后方的Ins / Cr和Glx / Cr比值，脾脏，右扣带后方和右扣带处的NAA / Cr。左后扣带状。我们还发现ADHD病例与右纹状体的Ins / Cr和NAA / Cr对照之间存在差异代谢物比率的相互作用。这些结果表明：1）在其他研究中，NAA / Cr，Glx / Cr和Ins / Cr比率在ADHD病例和对照组之间显示出显着差异； 2）ADHD病例和对照之间这些代谢物比率的差异会随着年龄的增长以特定的和可识别的模式演变，这一发现可以复制以前通过结构MRI获得的结果，这表明在ADHD病例和对照中脑个体发育遵循不同的程序； 3）右侧纹状体的Ins / Cr和NAA / Cr比值以ADHD病例与对照之间的差异方式相互作用。总体而言，这些结果重复了先前的1H-MRS研究结果，并在ADHD病例和对照之间增加了新的有趣的新陈代谢差异和个体发育模式，值得进一步研究。

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