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Cholesterol-Induced Membrane Microvesicles As Novel Carriers of Damage–Associated Molecular Patterns Mechanisms of Formation Action and Detoxification

机译：胆固醇诱导的膜微粒子作为损伤相关分子模式的新型载体的形成动作和排毒

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ObjectiveCholesterol enrichment occurs in vivo when phagocytes ingest retained and aggregated lipoproteins, damaged or senescent cells, and related debris. We previously reported that enrichment of human monocyte/macrophages with unesterified cholesterol (UC) triggers the release of highly procoagulant microvesicles ([MVs], also called microparticles) through induction of apoptosis. We determined whether UC-induced MVs (UCMVs) might transmit endogenous danger signals and, if so, what molecular processes might be responsible for their production, recognition, and detoxification.

机译：当吞噬保留和聚集的脂蛋白，受损或衰老细胞和相关的碎片时，在体内发生客观的富集发生。我们以前报道，用未酯的胆固醇（UC）富集人单核细胞/巨噬细胞通过诱导细胞凋亡来诱发高度探测剂微泡（[MVS]，也称为微粒）的释放。我们确定了UC诱导的MVS（UCMVs）是否可以传输内源危险信号，如果是，则可能对其生产，识别和解毒负责哪种分子过程。

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期刊名称 other
作者
Ming-Lin Liu; Rosario Scalia; Jawahar L. Mehta; Kevin Jon Williams;
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年(卷),期 -1(32),9
年度 -1
页码 2113–2121
总页数 21
原文格式 PDF
正文语种
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关键词
microvesicles microparticles damage–associated molecular patterns cholesterol monocytes endothelium;

机译：微泡;微粒;与损伤相关的分子模式;胆固醇;单核细胞;内皮;

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专利

1. Cholesterol-induced membrane microvesicles as novel carriers of damage-associated molecular patterns: Mechanisms of formation, action, and detoxification [J] . LiuM.-L., ScaliaR., MehtaJ.L., Arteriosclerosis, thrombosis, and vascular biology . 2012,第9期

机译：胆固醇诱导的膜微囊泡是与损伤相关的分子模式的新型载体：形成，作用和排毒的机制。
2. Chapter 3: acquisition of membrane polarity in epithelial tube formation patterns, signaling pathways, molecular mechanisms, and disease. [J] . Martin Belmonte F, Rodriguez Fraticelli AE International review of cell and molecular biology . 2009,第Null期

机译：第3章：获取上皮管形成模式，信号传导途径，分子机制和疾病中的膜极性。
3. Indolicidin action on membrane permeability: carrier mechanism versus pore formation. [J] . Rokitskaya TI, Kolodkin NI, Kotova EA, Biochimica et biophysica acta. Biomembranes . 2011,第1期

机译：吲哚美定对膜渗透性的作用：载体机理与孔形成。
4. Understanding Membrane Fouling Mechanisms (I): Molecular Simulations of Foulant-Membrane Interactions [C] . Yuan Xiang Annual Meeting of the North American Membrane Society . 2012

机译：了解膜污垢机制（i）：污染膜相互作用的分子模拟
5. Molecular mechanisms of gating, selectivity, and transport in membrane channels and carriers [D] . Wang, Yi 2008

机译：膜通道和载体中门控，选择性和转运的分子机理
6. PNAS Plus: Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns [O] . Soo Jeong Park, Jeong Mi Kim, Jihyo Kim, 2018

机译：PNAS Plus：凋亡性外泌体样小囊的生物发生的分子机制及其作为损伤相关分子模式的作用
7. Cholesterol-Induced Membrane Microvesicles As Novel Carriers of Damage–Associated Molecular Patterns [O] . Ming-Lin Liu, Rosario Scalia, Jawahar L. Mehta, 2012

机译：胆固醇诱导的膜微粒子作为损伤相关分子模式的新型载体

Cholesterol-Induced Membrane Microvesicles As Novel Carriers of Damage–Associated Molecular Patterns Mechanisms of Formation Action and Detoxification

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