• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >A human laboratory study investigating the effects of quetiapine on marijuana withdrawal and relapse in daily marijuana smokers
【2h】

A human laboratory study investigating the effects of quetiapine on marijuana withdrawal and relapse in daily marijuana smokers

机译：一个人的实验室研究调查喹硫平对大麻撤出和复发的日常吸食大麻的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Marijuana withdrawal contributes to the high relapse rates in individuals seeking treatment for marijuana-use disorders. Quetiapine, an atypical antipsychotic, reduces characteristic symptoms of marijuana withdrawal in a variety of psychiatric conditions including mood lability, sleep disruption, and anorexia. This human laboratory study investigated the effectiveness of quetiapine to decrease marijuana withdrawal and relapse to marijuana use in nontreatment seeking marijuana smokers. Volunteers were maintained on placebo or quetiapine (200 mg/day) in this double-blind, counter-balanced, within-subject study consisting of two 15-day medication phases, the last 8 days of which were inpatient. On the first inpatient day, active marijuana (6.2% delta (9)-tetrahydrocannabinol [THC]) was repeatedly smoked under controlled conditions. For the next 3 days, inactive marijuana (0.0% THC) was available for self-administration (withdrawal). On the subsequent 4 days, active marijuana (6.2% THC) was available for self-administration (relapse). Volunteers (n = 14) who smoked an average of 10 marijuana cigarettes/day, 7 days/week completed the study. Under placebo, withdrawal was marked by increased subjective ratings of negative mood, decreased sleep quality, decreased caloric intake, and weight loss. Compared to placebo, quetiapine improved sleep quality, increased caloric intake, and decreased weight loss. However, quetiapine increased marijuana craving and marijuana self-administration during the relapse phase. These data do not suggest that quetiapine shows promise as a potential treatment for marijuana dependence.
机译：大麻撤回有助于寻求大麻用障碍治疗的个人高复发利率。喹诗，一种非典型抗精神病药，减少了各种精神病条件下大麻戒断的特征症状，包括情绪较大，睡眠中断和厌食症。该人类实验室研究调查了喹硫碱的有效性将大麻撤离和复发到大麻使用的非经营中寻求大麻吸烟者。在这种双盲，反平衡的受试者内研究中，志愿者在安慰剂或喹喔酮（200毫克/天）维持，其中由两个15天的药物阶段组成，其中8天是住院病人。在第一天，活跃大麻（6.2％δ（9） - 四羟基吲哚酚[THC]）在受控条件下反复熏制。在接下来的3天内，可用大麻（0.0％THC）可用于自我管理（退出）。在随后的4天内，Active Marijuana（6.2％THC）可用于自我管理（复发）。志愿者（n = 14）均为平均吸烟10条大麻香烟/日，7天/周完成了这项研究。在安慰剂下，通过增加负面情绪的主观评级，减少睡眠质量，减少热量，减肥和减肥，标志着提取。与安慰剂相比，喹硫曲线改善了睡眠质量，增加了热量增加，减少了减重。然而，Quetiapine在复发阶段增加了大麻渴望和大麻自我管理。这些数据并不建议Quetiapine将承诺作为大麻依赖的潜在治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号