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New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

机译:新的见解核和染色质结构:一个有序的状态或无序的事?

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摘要

The compaction of genomic DNA into chromatin has profound implications for the regulation of key processes such as transcription, replication and DNA repair. Nucleosomes, the repeating building blocks of chromatin, vary in the composition of their histone protein components. This is the result of the incorporation of variant histones and post-translational modifications of histone amino acid side chains. The resulting changes in nucleosome structure, stability and dynamics affect the compaction of nucleosomal arrays into higher-order structures. It is becoming clear that chromatin structures are not nearly as uniform and regular as previously assumed. This implies that chromatin structure must also be viewed in the context of specific biological functions.
机译:基因组DNA进入染色质的压实对诸如转录,复制和DNA修复的关键过程的调节具有深远的影响。核桃瘤,染色质的重复构建块,在其组蛋白组分的组合物中变化。这是掺入变体组蛋白的结果和组蛋白氨基酸侧链的翻译后修饰。由此产生的核小体结构,稳定性和动力学的变化影响核体阵列的压实到高阶结构。显然,如前所述,染色质结构并不像以前一样均匀且常规。这意味着还必须在特定生物学功能的背景下观察染色质结构。

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