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Family History of Myocardial Infarction Is a Risk Factor for Venous Thromboembolism Among Whites But Not Among Blacks

机译:心肌梗死的家族史是白人静脉血栓栓塞但不含黑人的危险因素

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摘要

In addition to potentially sharing common pathogenesis and clinical manifestations, venous and arterial thromboses might have overlapping risk factors. To evaluate the family history of myocardial infarction (MI) as a risk factor for venous thromboembolism (VTE) among whites and blacks, we analyze data from the Genetic Attributes and Thrombosis Epidemiology (GATE) study. Results indicate that the association between VTE and a family history of MI is statistically significant only among whites (odds ratio [OR] = 1.3; 95% confidence interval [CI] = 1.03-1.8), particularly when they have diabetes mellitus (OR = 3.1; 95% CI = 1.2-8.0). Among blacks, the association between VTE and a family history of MI is not statistically significant (OR = 1.2; 95% CI = 0.89-1.5) either among those with diabetes or those without diabetes. We conclude that a family history of MI is a risk factor for VTE among certain populations stratified by race and comorbid conditions.
机译:除了潜在分享常见的发病机制和临床表现外,静脉和动脉血栓形成可能具有重叠的危险因素。为了评估心肌梗死(MI)的家族史作为白人和黑色静脉血栓栓塞(VTE)的危险因素,我们分析来自遗传属性和血栓形成流行病学(门)研究的数据。结果表明,vte之间的关联和Mi的家族史上只有在白人之间存在统计学意义(差距[或] = 1.3; 95%置信区间[CI] = 1.03-1.8),特别是当它们有糖尿病(或= 3.1; 95%CI = 1.2-8.0)。在黑人中,VTE之间的关联和MI的家族史无论是否存在糖尿病或没有糖尿病那些患者的统计学意义(或= 1.2; 95%CI = 0.89-1.5)。我们得出结论,MI的家族史是VTE的危险因素,这些群体在种族和合并条件分层的某些人口中。

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