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首页> 美国卫生研究院文献>other >A Polymorphic Indel Containing the RS3 Microsatellite in the 5’ Flanking Region of the Vasopressin V1a Receptor Gene is Associated with Chimpanzee (Pan troglodytes) Personality
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A Polymorphic Indel Containing the RS3 Microsatellite in the 5’ Flanking Region of the Vasopressin V1a Receptor Gene is Associated with Chimpanzee (Pan troglodytes) Personality

机译：一个多态含个Indel的Rs3微在加压素V1a受体基因5’ 侧翼区是有关联的黑猩猩（黑猩猩）个性

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摘要

Vasopressin is a neuropeptide that has been strongly implicated in the development and evolution of complex social relations and cognition in mammals. Recent studies in voles have shown that polymorphic variation in the promoter region of the arginine vasopressin V1a receptor gene (avpr1a) is associated with different dimensions of sociality. In humans, variation in a repetitive sequence element in the 5’ flanking region of the AVPR1A, known as RS3, have also been associated with variation in AVPR1a gene expression, brain activity and social behavior. Here, we examined the association of polymorphic variation in this same 5’ flanking region of the AVPR1A on subjective ratings of personality in a sample of 83 chimpanzees (Pan troglodytes). Initial analyses indicated that 34 females and 19 males were homozygous for the short allele, which lacks RS3(DupB−/−); while 18 females and 12 males were heterozygous and thus had one copy of the long allele containing RS3 (DupB+/−), yielding overall allelic frequencies of 0.82 for the DupB− allele and 0.18 for the DupB+ allele. DupB+/+ chimpanzees were excluded from the analysis due to the limited number of individuals. Results indicated no significant sex difference in personality between chimpanzees homozygous for the deletion of the RS3-containing DupB region (DupB−/−); however, among chimpanzees carrying one allele with the DupB present (DupB+/−), males had significantly higher dominance and lower conscientiousness scores than females. These findings are the first evidence showing that the AVPR1A gene plays a role in different aspects of personality in male and female chimpanzees.
机译：血管加压素是一种神经肽，这一直暗中涉及复杂的社会关系和哺乳动物认知的发展和演变。最近的葡萄节的研究表明，精氨酸血管加压素V1A受体基因（AVPR1A）的启动子区的多态变化与社会性的不同维度有关。在人类中，AVPR1A的5'侧翼区域中的重复序列元素的变化也与AVPR1A基因表达，脑活动和社会行为的变异有关。在这里，我们检查了AVPR1A的相同5'侧翼区域在83黑猩猩（PAN Troglodytes）中具有个性的主观评级的相同5'侧翼区域中的多态性变化的关联。初始分析表明，34名女性和19名男性对短等位基因纯合的，其缺乏RS3（Dupb - / - / sup>）;虽然18名女性和12个男性是杂合的，因此具有含有RS3的长等位基因的一种拷贝（Dupb +/- ），因此对于Dupb - 产生0.82的总体等位基因频率等位基因和0.18用于DUPB + 等位基因。由于个人数量有限，Dupb + / +黑猩猩被排除在分析之外。结果表明，纯合在缺失RS3的DUPB区域的黑猩猩之间的个性性差异（DUPB - / - / - / sup>）;然而，在携带一种等位基因的黑猩猩中，伴随着Dupb（Dupb +/- ），男性的优势明显更高，劣征性比女性更高。这些发现是第一个证据表明AVPR1A基因在男性和女性黑猩猩的人格不同方面发挥作用。

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