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Applicability of the Nonverbal Learning Disability Paradigm for Children With 22q11.2 Deletion Syndrome

机译：22Q11.2缺失综合征儿童非语言学习障碍范例的适用性

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摘要

Chromosome 22q11.2 deletion syndrome (22q11DS) is the most common microdeletion in humans. Nonverbal learning disability (NLD) has been used to describe the strengths and deficits of children with 22q11DS, but the applicability of the label for this population has seldom been systematically evaluated. The goal of the current study was to address how well the NLD diagnosis characterizes children and adolescents with 22q11DS. A total of 74 children and adolescents with 22q11DS were given neurocognitive, socioemotional, and academic assessments to measure aspects of NLD. Of the cohort, 20% met at least 7 of 9 assessed criteria for NLD; 25% showed verbal skills exceeding their nonverbal skills as assessed by an IQ test; and 24% showed the good rote verbal capacity commonly associated with NLD. Hypothesizing that if the entire cohort did not show consistent NLD characteristics, the descriptor might be more accurate for a distinct subgroup, the authors used latent class analysis to divide participants into three subgroups. However, the lines along which the groups broke out were more related to general functioning level than to NLD criteria. All three groups showed a heightened risk for psychiatric illness, highlighting the importance of careful mental health monitoring for all children with 22q11DS.
机译：染色体22Q11.2删除综合征（22Q11DS）是人类中最常见的微缺。非语言学习残疾（NLD）已被用于描述22Q11DS儿童的优势和赤字，但标签的适用性很少被系统地评估。目前的研究的目标是解决NLD诊断的特征在于22Q11D的儿童和青少年的表现。共有74名儿童和青少年具有22Q11DS的神奇认知，社会间谍和学术评估，以衡量NLD的方面。队列，20％达到了9种评估标准的至少7个符合NLD; 25％的口头技能超出了智商测试评估的非语言技能; 24％显示与NLD共同相关的良好死记硬背言语能力。假设如果整个队列未显示一致的NLD特征，则描述符可能更准确地对一个不同的子组，所以作者使用潜在的类分析将参与者分为三个子组。然而，与常规运作水平更相关的是与NLD标准更相关的线。所有三个团体对精神疾病的风险显现出了高度的风险，突出了对22Q11DS所有儿童进行仔细心理健康监测的重要性。

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