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MEG-SIM: A Web Portal for Testing MEG Analysis Methods using Realistic Simulated and Empirical Data

机译:mEG-sIm:门户网站对mEG的测试分析方法使用现实模拟与实证数据

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摘要

MEG and EEG measure electrophysiological activity in the brain with exquisite temporal resolution. Because of this unique strength relative to noninvasive hemodynamic-based measures (fMRI, PET), the complementary nature of hemodynamic and electrophysiological techniques is becoming more widely recognized (e.g., Human Connectome Project). However, the available analysis methods for solving the inverse problem for MEG and EEG have not been compared and standardized to the extent that they have for fMRI/PET. A number of factors, including the non-uniqueness of the solution to the inverse problem for MEG/EEG, have led to multiple analysis techniques which have not been tested on consistent datasets, making direct comparisons of techniques challenging (or impossible). Since each of the methods is known to have their own set of strengths and weaknesses, it would be beneficial to quantify them. Toward this end, we are announcing the establishment of a website containing an extensive series of realistic simulated data for testing purposes (). Here, we present: 1) a brief overview of the basic types of inverse procedures; 2) the rationale and description of the testbed created; and 3) cases emphasizing functional connectivity (e.g., oscillatory activity) suitable for a wide assortment of analyses including independent component analysis (ICA), Granger Causality/Directed transfer function, and single-trial analysis.
机译:Meg和EEG以精致的时间分辨率测量大脑的电生理活性。由于这种独特的强度相对于非侵入性血液动力学措施(FMRI,PET),血流动力学和电生理技术的互补性具有更广泛认可的(例如,人类连接项目)。然而,尚未将用于解决MEG和EEG的逆问题的可用分析方法,并在适用于FMRI / PET的程度上进行比较和标准化。许多因素包括对MEG / EEG的逆问题的解决方案的非唯一性,导致了多个分析技术,这些技术尚未在一致的数据集上进行测试,从而直接比较技术挑战(或不可能)。由于已知每种方法都有自己的强度和弱点,因此量化它们是有益的。为此,我们正在宣布建立一个网站,其中包含一个用于测试目的的广泛逼真的模拟数据的网站()。在这里,我们展示:1)简要概述逆程序的基本类型; 2)测试的理由和描述; 3)强调功能性连接(例如,振荡活动)适用于各种各样的分析,包括独立组分分析(ICA),Granger因果关系/定向传递函数和单试分分析。

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