• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Isotope Enhanced Approaches in Metabolomics
【2h】

Isotope Enhanced Approaches in Metabolomics

机译：同位素代谢改进办法

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The rapidly growing area of “metabolomics,” in which a large number of metabolites from body fluids, cells or tissue are detected quantitatively, in a single step, promises immense potential for a number of disciplines including early disease diagnosis, therapy monitoring, systems biology, drug discovery and nutritional science. Because of its ability detect a large number of metabolites in intact biological samples reproducibly and quantitatively, nuclear magnetic resonance (NMR) spectroscopy has emerged as one of the most powerful analytical techniques in metabolomics. NMR spectroscopy of biological samples with isotope labeling of metabolites using nuclei such as 2H, 13C, 15N and 31P, either in vivo or ex vivo, has dramatically improved our ability to identify low concentrated metabolites and trace important metabolic pathways. Considering the somewhat limited sensitivity of NMR and high complexity of the spectra of biological samples, increased sensitivity and selectivity achieved through isotope labeling methods pave novel avenues to unravel biological complexity and understand cellular functions in health and various disease conditions. This chapter describes the current developments in isotope labeling of metabolites in vivo as well as ex vivo, and their potential metabolomics applications.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号