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Responses of Human Skin in Organ Culture and Human Skin Fibroblasts to a Gadolinium-Based MRI Contrast Agent: Comparison of Skin from Patients with End-Stage Renal Disease and Skin from Healthy Subjects

机译：人体皮肤在器官培养和人体皮肤成纤维细胞对基于钆的MRI造影剂中的反应：从健康受试者患有终末期肾病和皮肤患者的皮肤比较

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ObjectiveNephrogenic systemic fibrosis (NSF) is a clinical syndrome occurring in a small subset of patients with end stage renal disease (ESRD). Exposure to certain of the gadolinium-based contrast agents (GBCAs) during magnetic resonance imaging appears to be a trigger. The pathogenesis of the disease is largely unknown. The present study addresses potential patho-physiological mechanisms.

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期刊名称 other
作者
Marissa DaSilva; Monica O’Brien Deming; Suzanne E.G. Fligiel; Michael K. Dame; Kent J. Johnson; Richard D. Swartz; James Varani;
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年(卷),期 -1(45),11
年度 -1
页码 733–739
总页数 16
原文格式 PDF
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关键词
gadolinium-based contrast agent (GBCA) hyaluronan matrix metalloproteinase I (MMP-1) nephrogenic systemic fibrosis (NSF) Omniscan tissue inhibitor of metalloproteinases-1 (TIMP-1) type I procollagen;

机译：lin基造影剂（GBCA）;透明质酸;基质金属蛋白酶I（MMP-1）;肾原性系统纤维化（NSF）;Omniscan;金属蛋白酶1组织抑制剂（TIMP-1）;I型原胶原;

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1. Responses of human skin in organ culture and human skin fibroblasts to a gadolinium-based MRI contrast agent: comparison of skin from patients with end-stage renal disease and skin from healthy subjects. [J] . DaSilva M, OBrien Deming M, Fligiel SE, Investigative radiology . 2010,第11期

机译：人体器官培养物中的皮肤和人类皮肤成纤维细胞对基于lin的MRI造影剂的反应：晚期肾病患者的皮肤与健康受试者的皮肤的比较。
2. Effects of gadolinium-based magnetic resonance imaging contrast agents on human skin in organ culture and human skin fibroblasts. [J] . Varani J, DaSilva M, Warner RL, Investigative radiology . 2009,第2期

机译：organ基磁共振成像造影剂对器官培养和人皮肤成纤维细胞中人皮肤的影响。
3. Collagenolytic activity is suppressed in organ-cultured human skin exposed to a gadolinium-based MRI contrast agent. [J] . Perone PA, Weber SL, DaSilva Investigative radiology . 2010,第1期

机译：暴露于a基MRI造影剂的器官培养的人皮肤中，胶原蛋白分解活性受到抑制。
4. Exogenous delta-animolevulinic acid induces the porphyrin biosynthesis in human skin organ cultures with different porphyrin patterns in normal and malignant human tissue [C] . Clemens Fritsch, Heinrich-Heine-Univ., Duesseldorf, 5th International Photodynamic Association Biennial Meeting . 1995

机译：外源性δ-苯氨基戊酸在人体和恶性人体组织中以不同的卟啉模式诱导人皮肤器官培养物中卟啉的生物合成
5. Perivascular Fibroblast Activation States in Human Skin Diseases [D] . Barron, Alexander Michael Shuford. 2020

机译：人体皮肤病中的血管血管成纤维细胞活化状态
6. Collagenolytic Activity is Suppressed in Organ-Cultured Human Skin Exposed to a Gadolinium-Based MRI Contrast Agent [O] . Patricia A. Perone, Stephanie L. Weber, Marissa DaSilva, -1

机译：在暴露于基于钆的MRI造影剂的器官培养的人体皮肤中抑制了胶原溶液活性
7. Responses of Human Skin in Organ Culture and Human Skin Fibroblasts to a Gadolinium-Based MRI Contrast Agent [O] . Marissa DaSilva, Monica OʼBrien Deming, Suzanne E. G. Fligiel, 2010

机译：人体皮肤在器官培养和人体皮肤成纤维细胞中的酸碱基MRI造影剂的反应

Responses of Human Skin in Organ Culture and Human Skin Fibroblasts to a Gadolinium-Based MRI Contrast Agent: Comparison of Skin from Patients with End-Stage Renal Disease and Skin from Healthy Subjects

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