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首页> 美国卫生研究院文献>other >Utilization of micelles formed from poly(ethylene glycol)-block-poly(ε-caprolactone) block copolymers as nanocarriers to enable hydrophobic red two-photon absorbing (2PA) emitters for cells imaging
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Utilization of micelles formed from poly(ethylene glycol)-block-poly(ε-caprolactone) block copolymers as nanocarriers to enable hydrophobic red two-photon absorbing (2PA) emitters for cells imaging

机译：利用聚（乙二醇）-Block-聚（ε-己内酯）嵌段共聚物形成的胶束作为纳米载体使疏水性红色双光子吸收（2Pa）发射器用于细胞成像

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A hydrophobic two-photon absorbing (2PA) red emitter (>R) was successfully incorporated into micelles formed from two block copolymers, poly(ε-caprolactone)-block-poly(ethylene glycol)s, for imaging and toxicity studies. In micelles, the chromophore >R exhibits a 2PA cross-section of 400 GM (1 GM =1×10−50 cm4 s photon−1 molecule−1) at 820 nm, which is among the highest values reported for red 2PA emitters. The micelles with a cationic amino moiety-containing poly(ethylene glycol) corona showed an enhancement of cell internalization and delivered the dye into the cytoplasmic regions of the mouse macrophage RAW 264.7 cells. In comparison, the dye in micelles with neutral poly(ethylene glycol) as corona could not be delivered into the cells. Cytotoxicity of the micelle->R constructs was studied using a 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. More than 90% of the cells were viable after they were stained with the dye-containing micelles at different concentrations (dye concentrations of 2 – 6 μM and polymer concentrations of 0.05 – 0.15 mg/mL) for 16 hours. This is the first reported application of a hydrophobic 2,1,3-benzothiadiazole-containing 2PA red emitter delivered into the cytoplasm of cells for bioimaging and toxicity assessment.

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