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Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains

机译:从考古遗迹中检索到的墨西哥殖民地历史性梅毒螺旋体基因组

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摘要

Treponema pallidum infections occur worldwide causing, among other diseases, syphilis and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious disease with millions of new infections annually. Here we present three historic T. pallidum genomes (two from T. pallidum ssp. pallidum and one from T. pallidum ssp. pertenue) that have been reconstructed from skeletons recovered from the Convent of Santa Isabel in Mexico City, operational between the 17th and 19th century. Our analyses indicate that different T. pallidum subspecies caused similar diagnostic presentations that are normally associated with syphilis in infants, and potential evidence of a congenital infection of T. pallidum ssp. pertenue, the causative agent of yaws. This first reconstruction of T. pallidum genomes from archaeological material opens the possibility of studying its evolutionary history at a resolution previously assumed to be out of reach.
机译:梅毒螺旋体感染在全球范围内引起,除其他疾病外,还引起梅毒和偏航。特别是,性传播梅毒被认为是一种每年重新出现的感染性疾病,每年有数百万新感染。在这里,我们介绍了三个具有历史意义的苍白锥虫基因组(两个来自苍白锥虫Spal。pallidum,一个来自苍白锥虫Sten。paltenum),这些基因组是从墨西哥城圣伊莎贝尔修道院恢复的骨骼中重建的,在17 sup> th 和19 世纪。我们的分析表明,不同的梅毒螺旋体亚种引起相似的诊断表现,通常与婴儿梅毒有关,并且是先天性梅毒螺旋体感染的潜在证据。永久性的,偏航的病因。从考古材料中首次建立苍白锥虫基因组,这为研究其进化历史提供了可能,而该分辨率以前被认为无法达到。

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