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Association between the response to TNF-antagonists and plasma type I interferon activity and interferon-beta/alpha ratios in rheumatoid arthritis patients: a post-hoc analysis of a predominantly Hispanic Cohort

机译:响应于TNF拮抗剂和血浆I型干扰素活性和干扰素-β之间的关联/α-比率在类风湿性关节炎患者:主要为西班牙裔队列的事后分析

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摘要

ObjectiveDespite substantial clinical efficacy of tumor necrosis factor-α (TNF)-antagonist therapy in patients with rheumatoid arthritis (RA), some patients respond poorly to such agents. Since an interferon (IFN) signature is variably expressed among RA patients, we investigated whether plasma type I IFN activity might predict response to TNF-antagonist therapy.

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