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Simulations of Measured Photobleaching Kinetics in Human Basal Cell Carcinomas Suggest Blood Flow Reductions During ALA-PDT

机译：人体基础细胞癌中测量的光博脉动力学模拟表明ALA-PDT期间的血液流量减少

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Background and ObjectiveIn a recently completed pilot clinical study at Roswell Park Cancer Institute, patients with superficial basal cell carcinoma (sBCC) received topical application of 20% 5-aminolevulinic acid (ALA) and were irradiated with 633 nm light at 10–150 mW cm⁻². Protoporphyrin IX (PpIX) photobleaching in the lesion and the adjacent perilesion normal margin was monitored by fluorescence spectroscopy. In most cases, the rate of bleaching slowed as treatment progressed, leaving a fraction of the PpIX unbleached despite sustained irradiation. To account for this feature, we hypothesized a decrease in blood flow during ALA-photodynamic therapy (PDT) that reduced the rate of oxygen transported to the tissue and therefore attenuated the photobleaching process. We have performed a detailed analysis of this hypothesis.

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作者
Ken Kang-Hsin Wang; William J. Cottrell; Soumya Mitra; Allan R. Oseroff; Thomas H. Foster;
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年(卷),期 -1(41),9
年度 -1
页码 686–696
总页数 20
原文格式 PDF
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关键词
photodynamic therapy skin cancer fluorescence spectroscopy protoporphyrin IX;

机译：光动力疗法;皮肤癌;荧光光谱法;原卟啉IX;

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1. Protoporphyrin IX photobleaching of subcellular distributed sites of leukemic HL60 cells based on ALA-PDT in vitro [J] . Kangqiang Huang, Li Chen, Shunfeng Lv, Journal of Biomedical Science and Engineering . 2012,第9期

机译：基于ALA-PDT的白血病HL60细胞亚细胞分布部位的原卟啉IX光漂白
2. A Continuum Model for Platelet Transport in Flowing Blood Based on Direct Numerical Simulations of Cellular Blood Flow [J] . Mehrabadi Marmar, Ku David N., Aidun Cyrus K. Annals of Biomedical Engineering: The Journal of the Biomedical Engineering Society . 2015,第6期

机译：基于细胞血流直接数值模拟的流动血液中血小板运输的连续模型
3. Depletion-model-based numerical simulation of the kinetics of red blood cell aggregation under sinusoidal pulsatile flow [J] . Lee Cheong-Ah, Kong Qi, Paeng Dong-Guk Biorheology . 2018,第1期

机译：基于耗竭模型的正弦脉动流下红细胞聚集动力学的数值模拟
4. Comparison between mALA- and ALA-PDT in the treatment of basal cell carcinomas [C] . Schleier Peter, Zenk Witold, Hyckel Peter, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV; Progress in Biomedical Optics and Imaging; vol.7 no.25 . 2006

机译：mALA-和ALA-PDT在基底细胞癌治疗中的比较
5. Simulation of blood flow using kinetic theory based multiphase model. [D] . Huang, Jing. 2009

机译：使用基于动力学理论的多相模型模拟血流。
6. Computational fluid dynamic simulation of human carotid artery bifurcation based on anatomy and volumetric blood flow rate measured with magnetic resonance imaging [O] . Hamidreza Gharahi, Byron A. Zambrano, David C. Zhu, -1

机译：基于解剖学和磁共振成像测量的体积血流速率的人颈动脉分叉计算流体动力学模拟
7. Computational fluid dynamic simulation of human carotid artery bifurcation based on anatomy and volumetric blood flow rate measured with magnetic resonance imaging [O] . Hamidreza Gharahi, Byron A. Zambrano, David C. Zhu, 2016

机译：基于磁共振成像测量的解剖学和体积血流量的人颈动脉分叉的计算流体动态模拟

Simulations of Measured Photobleaching Kinetics in Human Basal Cell Carcinomas Suggest Blood Flow Reductions During ALA-PDT

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