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Short Echo Spectroscopic Imaging of the Human Brain at 7T Using Transceiver Arrays

机译：利用人脑的短回波波谱成像在7T收发器阵列

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Recent advances in magnet technology have enabled the construction of ultra high-field magnets (7T and higher) that can accommodate the human head and body. Despite the intrinsic advantages of performing spectroscopic imaging at 7T, increased SNR and spectral resolution, few studies have been reported to date. This limitation is largely due to increased power deposition and B1 inhomogeneity. To overcome these limitations, we have utilized an 8 channel transceiver array with a short TE (15 ms) spectroscopic imaging sequence. Utilizing phase and amplitude mapping and optimization schemes, the 8 element transceiver array provided both improved efficiency, (17% less power for equivalent peak B1) and homogeneity (SD(B1) =±10% versus ±22%) in comparison to a transverse electromagnetic (TEM) volume coil. To minimize the echo time to measure J-modulating compounds such as glutamate, we developed a short TE sequence utilizing a single slice selective excitation pulse followed by a broad band semi-selective refocusing pulse. Extracerebral lipid resonances were suppressed with an inversion recovery pulse and delay. The short TE sequence enabled visualization of a variety of resonances, including glutamate in both a control subject and a patient with a grade II oligodendroglioma.

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