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首页> 美国卫生研究院文献>other >The effectiveness of 4 monthly albendazole for the reduction of soil-transmitted helminth infections in women of reproductive age in Viet Nam
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The effectiveness of 4 monthly albendazole for the reduction of soil-transmitted helminth infections in women of reproductive age in Viet Nam

机译：越南生殖年龄妇女妇女妇女减少4月阿育唑的有效性

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Soil-transmitted helminth (STH) infections are endemic in northern Viet Nam where the climate and agricultural practices, such as the use of human excreta as fertiliser and the use of wastewater for irrigation, favour transmission. An intervention was conducted in Yen Bai Province, north-west Viet Nam, to measure the effectiveness of single dose albendazole (400 mg) administered every 4 months for reducing the prevalence of STH infections in women of reproductive age. Stool samples were collected from women before the intervention and 3 and 12 months post intervention. Information on a range of demographic and socio-economic variables was also collected to measure the major risk factors for high STH burden in this area. The prevalence of hookworm, Ascaris lumbricoides, and Trichuris trichiura infection in the baseline sample of 366 women were 76.2%, 19.2% and 29.1% respectively. In the women who were surveyed at baseline and again at 3 and 12 months after the intervention (N=118) cure rates were 71.3% for hookworm, 87.0% for A. lumbricoides and 81.4% for T. trichiura by the end of the 12 month study period (i.e. with 3 doses of albendazole). The main risk factor for hookworm infection was if a women worked outside [OR =3.2 (95% CI 1.6-6.2), p=0.001] and the major risk factor for A. lumbricoides and T. trichiura infection was a lack of education. Low educational attainment was also the strongest risk factor for co-infection with all three species of STH [OR= 7.5 (95% CI 3.4-16.4), p<0.001]. The high rates of hookworm infection in this area of Viet Nam and the high cure rates for all three species of STH with four monthly albendazole suggest that this program should be expanded to all endemic areas in Viet Nam. The study also highlights the important contribution of education to women’s health.

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