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The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG fMRI and volumetric techniques

机译：伏隔核和喙前扣带回皮层在快感缺乏症中的作用：静息脑电图功能磁共振成像和容积技术的整合

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Anhedonia, the reduced propensity to experience pleasure, is a promising endophenotype and vulnerability factor for several psychiatric disorders, including depression and schizophrenia. In the present study, we used resting electroencephalograms, functional magnetic resonance imaging, and volumetric analyses to probe putative associations between anhedonia and individual differences in key nodes of the brain’s reward system in a non-clinical sample. We found that anhedonia, but not other symptoms of depression or anxiety, was correlated with reduced nucleus accumbens (NAcc) responses to rewards (gains in a monetary incentive delay task), reduced NAcc volume, and increased resting delta current density (i.e., decreased resting activity) in the rostral anterior cingulate cortex (rACC), an area previously implicated in positive subjective experience. In addition, NAcc reward responses were inversely associated with rACC resting delta activity, supporting the hypothesis that delta might be lawfully related to activity within the brain’s reward circuit. Taken together, these results help elucidate the neural basis of anhedonia and strengthen the argument for anhedonia as an endophenotype for depression.
机译：快感缺乏享受乐趣的倾向，是包括抑郁症和精神分裂症在内的多种精神疾病的一种有前途的内表型和易感性因素。在本研究中，我们使用静息脑电图，功能磁共振成像和体积分析来探讨非临床样本中的快感缺乏症与大脑奖励系统关键结节的个体差异之间的推测关联。我们发现，快感不足，而不是其他抑郁或焦虑症状，与伏隔核（NAcc）对奖励的反应减少（通过金钱激励延迟任务获得），NAcc量减少以及静息电流密度增加（即，降低静息活动）在前额扣带回皮层（rACC）中，该区域先前涉及积极的主观体验。此外，NAcc的奖励反应与rACC静止的delta活动成反比，支持以下假设：delta可能与大脑奖励回路中的活动合法相关。综上所述，这些结果有助于阐明快感缺乏症的神经基础，并加强了将快感缺乏症作为抑郁症的内表型的观点。

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