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首页> 美国卫生研究院文献>PLoS Neglected Tropical Diseases >A 2015 outbreak of flea-borne rickettsiosis in San Gabriel Valley Los Angeles County California
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A 2015 outbreak of flea-borne rickettsiosis in San Gabriel Valley Los Angeles County California

机译：2015年加利福尼亚州洛杉矶县圣盖博谷地爆发了跳蚤传播的立克次体病

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Although flea-borne rickettsiosis is endemic in Los Angeles County, outbreaks are rare. In the spring of 2015 three human cases of flea-borne rickettsiosis among residents of a mobile home community (MHC) prompted an investigation. Fleas were ubiquitous in common areas due to presence of flea-infested opossums and overabundant outdoor cats and dogs. The MHC was summarily abated in June 2015, and within five months, flea control and removal of animals significantly reduced the flea population. Two additional epidemiologically-linked human cases of flea-borne rickettsiosis detected at the MHC were suspected to have occurred before control efforts began. Molecular testing of 106 individual and 85 pooled cat fleas, blood and ear tissue samples from three opossums and thirteen feral cats using PCR amplification and DNA sequencing detected rickettsial DNA in 18.8% of the fleas. Seventeen percent of these cat fleas tested positive for R. felis-specific DNA compared to under two (<2) percent for Candidatus R. senegalensis-specific DNA. In addition, serological testing of 13 cats using a group-specific IgG-ELISA detected antibodies against typhus group rickettsiae and spotted fever group rickettsiae in six (46.2%) and one (7.7%) cat, respectively. These results indicate that cats and their fleas may have played an active role in the epidemiology of the typhus group and/or spotted fever group rickettsial disease(s) in this outbreak.
机译：尽管跳蚤传播的立克次体病在洛杉矶县很流行，但疫情很少见。 2015年春季，活动房屋社区（MHC）居民中的三起人类跳蚤立克次体病病例引发了调查。由于存在跳蚤的负鼠和过多的户外猫狗，因此跳蚤在公共区域无处不在。 2015年6月，MHC总体上被消减，在五个月内，跳蚤的控制和动物的去除大大减少了跳蚤的数量。在控制工作开始之前，怀疑在MHC发现的另外2例与流行病学相关的人类跳蚤立克次体病病例。使用PCR扩增和DNA测序技术对来自3只负鼠和13只野猫的106只个体猫和85只合并的猫蚤，血液和耳朵组织样本进行分子测试，检测了18.8％的蚤中的立克次体DNA。这些猫蚤中有17％的猫科动物特异性DNA检测呈阳性，而塞内加尔假丝酵母的特异性DNA检测不到2％（<2）。此外，使用组特异性IgG-ELISA对13只猫进行血清学测试，分别在6只（46.2％）和1只（7.7％）猫中检测到抗斑疹伤寒立克次氏菌和斑点热立克次氏体的抗体。这些结果表明，猫和它们的跳蚤在这次疫情中可能在斑疹伤寒组和/或斑点热组立克次氏病的流行病学中发挥了积极作用。

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